NIMH Data Archive - Data

Genomics

Neuroimaging

Phenotype¹

New Trial
Clinical Trial

¹ Numbers reported are subjects by age

New Project
Grant/Project Number

Format should be in the following format: Activity Code, Institute Abbreviation, and Serial Number. Grant Type, Support Year, and Suffix should be excluded. For example, grant 1R01MH123456-01A1 should be entered R01MH123456

Collection - Use Existing Experiment

To associate an experiment to the current collection, just select an axperiment from the table below then click the associate experiment button to persist your changes (saving the collection is not required). Note that once an experiment has been associated to two or more collections, the experiment will not longer be editable.

The table search feature is case insensitive and targets the experiment id, experiment name and experiment type columns. The experiment id is searched only when the search term entered is a number, and filtered using a startsWith comparison. When the search term is not numeric the experiment name is used to filter the results.

Select	Experiment Id	Experiment Name	Experiment Type	Created On

24	HI-NGS_R1	Omics	02/16/2011
475	MB1-10 (CHOP)	Omics	06/07/2016
490	Discovery and CRISPR validation of genetic factors associated with antipsychotic-induced weight gain and cardiometabolic risk	Omics	07/07/2016
501	PharmacoBOLD Resting State	fMRI	07/27/2016
506	PVPREF	Omics	08/05/2016
509	ABC-CT Resting v2	EEG	08/18/2016
13	Comparison of FI expression in Autistic and Neurotypical Homo Sapiens	Omics	12/28/2010
18	AGRE/Broad Affymetrix 5.0 Genotype Experiment	Omics	01/06/2011
22	Stitching PCR Sequencing	Omics	02/14/2011
26	ASD_Methylation	Omics	03/01/2011
29	Microarray family 03 (father, mother, sibling)	Omics	03/24/2011
37	Standard paired-end sequencing of BCRs	Omics	04/19/2011
38	Illumina Mate-Pair BCR sequencing	Omics	04/19/2011
39	Custom Jumping Libraries	Omics	04/19/2011
40	Custom CapBP	Omics	04/19/2011
41	Immunofluorescence	Omics	05/11/2011
43	Autism brain sample genotyping, Illumina	Omics	05/16/2011
47	ARRA Autism Sequencing Collaboration at Baylor. SOLiD 4 System	Omics	08/01/2011
53	AGRE Omni1-quad	Omics	10/11/2011
59	AGP genotyping	Omics	04/03/2012
60	Ultradeep 454 sequencing of synaptic genes from postmortem cerebella of individuals with ASD and neurotypical controls	Omics	06/23/2012
63	Microemulsion PCR and Targeted Resequencing for Variant Detection in ASD	Omics	07/20/2012
76	Whole Genome Sequencing in Autism Families	Omics	01/03/2013
519	Resting	fMRI	11/08/2016
90	Genotyped IAN Samples	Omics	07/09/2013
91	NJLAGS Axiom Genotyping Array	Omics	07/16/2013
93	AGP genotyping (CNV)	Omics	09/06/2013
106	Longitudinal Sleep Study. H20 200. Channel set 2	EEG	11/07/2013
107	Longitudinal Sleep Study. H20 200. Channel set 3	EEG	11/07/2013
108	Longitudinal Sleep Study. AURA 200	EEG	11/07/2013
105	Longitudinal Sleep Study. H20 200. Channel set 1	EEG	11/07/2013
109	Longitudinal Sleep Study. AURA 400	EEG	11/07/2013
116	Gene Expression Analysis WG-6	Omics	01/07/2014
131	Jeste Lab UCLA ACEii: Charlie Brown and Sesame Street - Project 1	Eye Tracking	02/27/2014
132	Jeste Lab UCLA ACEii: Animacy - Project 1	Eye Tracking	02/27/2014
133	Jeste Lab UCLA ACEii: Mom Stranger - Project 2	Eye Tracking	02/27/2014
134	Jeste Lab UCLA ACEii: Face Emotion - Project 3	Eye Tracking	02/27/2014
145	AGRE/FMR1_Illumina.JHU	Omics	04/14/2014
146	AGRE/MECP2_Sanger.JHU	Omics	04/14/2014
147	AGRE/MECP2_Junior.JHU	Omics	04/14/2014
151	Candidate Gene Identification in familial Autism	Omics	06/09/2014
152	NJLAGS Whole Genome Sequencing	Omics	07/01/2014
154	Math Autism Study - Vinod Menon	fMRI	07/15/2014
155	Resting	fMRI	07/25/2014
156	Speech	fMRI	07/25/2014
159	Emotion	fMRI	07/25/2014
160	syllable contrast	EEG	07/29/2014
167	School-age naturalistic stimuli	Eye Tracking	09/19/2014
44	AGRE/Broad Affymetrix 5.0 Genotype Experiment	Omics	06/27/2011
45	Exome Sequencing of 20 Sporadic Cases of Autism Spectrum Disorder	Omics	07/15/2011

Collection - Add Experiment

Add Supporting Documentation

Funding Source:
URL:

To add an existing Data Structure, enter its title in the search bar. If you need to request changes, select the indicator "No, it requires changes to meet research needs" after selecting the Structure, and upload the file with the request changes specific to the selected Data Structure. Your file should follow the Request Changes Procedure. If the Data Structure does not exist, select "Request New Data Structure" and upload the appropriate zip file.

Use/Modify Existing Data Structure

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The Data Expected list for this Collection shows some raw data as missing. Contact the NDA Help Desk with any questions.

Please confirm that you will not be enrolling any more subjects and that all raw data has been collected and submitted.

Collection Updated

Your Collection is now in Data Analysis phase and exempt from biannual submissions. Analyzed data is still expected prior to publication or no later than the project end date.

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[CMS]

Unable to change collection phase where targeted enrollment is less than 90%

You have requested to move the sharing dates for the following assessments:

Data Expected Item	Original Sharing Date	New Sharing Date

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Early Life Stress and Depression: Molecular and Functional Imaging Approaches #3821

General
Experiments (2)
Shared Data
Publications (38)
Data Expected (27)
Associated Studies (1)

Collection Title	Collection Investigators	Collection Description
Collection Title:	Early Life Stress and Depression: Molecular and Functional Imaging Approaches
Collection Investigators:	Diego Pizzagalli; Fei Du
Collection Description:	Epidemiological studies have shown that severe childhood adversity explains 32-44 percent of psychiatric disorders, and is associated with 4.6-fold risk for depression and 6.6-fold risk for substance abuse later in life. In spite of these epidemiological data, the neurobiological underpinnings associated with maladaptive sequelae of CSA remain largely unknown. Preclinical research strongly suggests that early adversity leads to 1 structural abnormalities in medial prefrontal cortex regions critically implicated in stress regulation 2 increased oxidative stress and 3 glutamatergic abnormalities. The current competing renewal was specifically designed to prospectively test the contributions of these abnormalities in individuals exposed to CSA. Together, these studies will test the hypotheses that abnormalities within immuno-oxidative mechanisms, including abnormal balance of redox regulation, oxidative stress and glutamate metabolites are linked to MDD and CSA pathophysiology. We expect that interactions among these abnormalities 1 lead to excitatory inhibitory imbalance of local neuronal circuits and morphometrical abnormalities within key regions mPFC 2 are associated with key MDD phenotypes and 3 prospectively predict future symptoms and functioning. These goals will be achieved by evaluating young adult females with a history of CSA between the ages of 12-16years with a current MDDCSA group or former rMDDCSA group diagnosis of major depressive disorder. To disentangle CSA- vs. MDD-related effects, these groups will be compared to both healthy controls and MDD females without a history of CSA MDD group. All subjects N160 will be tested at both 3T and4T scanners using an integration of state-of-the-art 31P magnetic resonance spectroscopy MRS to quantify redox ratio and brain bioenergetics in vivo, high field multinuclear MRS to assess glutamate metabolites and glutathione, functional magnetic resonance imaging to probe the neural correlates of anhedonic behavior and cognitive control deficits. To track disease course, all participants will be prospectively assessed at 6- and 12-month follow-up sessions. Based on our extensive set of preliminary findings, we hypothesize that, relative to both healthy controls and the MDD group, MDDCSA individuals will show greater cortical thinning in the medial prefrontal cortex, lower redox ratio, lower glutamine glutamate ratio, and higher inflammatory markers Hypothesis 1. We further expect that these abnormalities will persist in euthymic rMDDCSA subjects, particularly with increasing number of lifetime depressive episodes. Moreover, we expect that these abnormalities will be associated with increased anhedonic behavior and cognitive deficits Hypotheses 2, and will predict an hedonic symptom, cognitive deficits and poorer general functioning at the follow-up assessments Hypothesis 3. Improving our understanding of neurobiological mechanisms associated with different CSA outcomes is of paramount importance in order to 1 identify individuals at risk for psychopathology and maladaptive behavior, 2 prevent revictimization, and 3 develop more targeted therapeutic interventions.
Data Repository:	NIMH Data Archive
Permission Group:
Collection Creation Date:	03/10/2021
Collection Phase:	Enrolling
Blinded Clinical Trial:	No
Total Funded Amount:	$3,923,648.00
Subjects Shared:	91
Collection DOI:	10.15154/hcy4-sg60

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Funding Sources:

Funding Source Name	Funding Source URL
NIH - Extramural	None

Supporting Documentation:

Grant Information:

Project Number	Title	Start Date	Original End Date	End Date	Planned Enrollment	Actual Enrollment	Organization	Funds Obligated
R01MH095809-05	Early Life Stress and Depression: Molecular and Functional Imaging Approaches	07/01/2020	04/30/2025	04/30/2026	160	136	MCLEAN HOSPITAL	$3,923,648.00

Clinical Trials:

helpcenter.collection.general-tab

Collection - General Tab

Fields available for edit on the top portion of the page include:

Collection Title
Investigators
Collection Description
Collection Phase
Funding Source
Clinical Trials

Collection Phase: The current status of a research project submitting data to an NDA Collection, based on the timing of the award and/or the data that have been submitted.

Pre-Enrollment: The default entry made when the NDA Collection is created.
Enrolling: Data have been submitted to the NDA Collection or the NDA Data Expected initial submission date has been reached for at least one data structure category in the NDA Collection.
Data Analysis: Subject level data collection for the research project is completed and has been submitted to the NDA Collection. The NDA Collection owner or the NDA Help Desk may set this phase when they’ve confirmed data submission is complete and submitted subject counts match at least 90% of the target enrollment numbers in the NDA Data Expected. Data submission reminders will be turned off for the NDA Collection.
Funding Completed: The NIH grant award (or awards) associated with the NDA Collection has reached its end date. NDA Collections in Funding Completed phase are assigned a subphase to indicate the status of data submission.
- The Data Expected Subphase indicates that NDA expects more data will be submitted
- The Closeout Subphase indicates the data submission is complete.
- The Sharing Not Met Subphase indicates that data submission was not completed as expected.

Blinded Clinical Trial Status:

This status is set by a Collection Owner and indicates the research project is a double blinded clinical trial. When selected, the public view of Data Expected will show the Data Expected items and the Submission Dates, but the targeted enrollment and subjects submitted counts will not be displayed.
Targeted enrollment and subjects submitted counts are visible only to NDA Administrators and to the NDA Collection or as the NDA Collection Owner.
When an NDA Collection that is flagged Blinded Clinical Trial reaches the maximum data sharing date for that Data Repository (see https://nda.nih.gov/nda/sharing-regimen.html), the embargo on Data Expected information is released.

Funding Source

The organization(s) responsible for providing the funding is listed here.

Supporting Documentation

Users with Submission privileges, as well as Collection Owners, Program Officers, and those with Administrator privileges, may upload and attach supporting documentation. By default, supporting documentation is shared to the general public, however, the option is also available to limit this information to qualified researchers only.

Grant Information

Identifiable details are displayed about the Project of which the Collection was derived from. You may click in the Project Number to view a full report of the Project captured by the NIH.

Clinical Trials

Any data that is collected to support or further the research of clinical studies will be available here. Collection Owners and those with Administrator privileges may add new clinical trials.

Frequently Asked Questions

How does the NIMH Data Archive (NDA) determine which Permission Group data are submitted into?

During Collection creation, NDA staff determine the appropriate Permission Group based on the type of data to be submitted, the type of access that will be available to data access users, and the information provided by the Program Officer during grant award.
How do I know when a NDA Collection has been created?

When a Collection is created by NDA staff, an email notification will automatically be sent to the PI(s) of the grant(s) associated with the Collection to notify them.
Is a single grant number ever associated with more than one Collection?

The NDA system does not allow for a single grant to be associated with more than one Collection; therefore, a single grant will not be listed in the Grant Information section of a Collection for more than one Collection.
Why is there sometimes more than one grant included in a Collection?

In general, each Collection is associated with only one grant; however, multiple grants may be associated if the grant has multiple competing segments for the same grant number or if multiple different grants are all working on the same project and it makes sense to hold the data in one Collection (e.g., Cooperative Agreements).

Glossary

Administrator Privilege

A privilege provided to a user associated with an NDA Collection or NDA Study whereby that user can perform a full range of actions including providing privileges to other users.
Collection Owner

Generally, the Collection Owner is the contact PI listed on a grant. Only one NDA user is listed as the Collection owner. Most automated emails are primarily sent to the Collection Owner.
Collection Phase
The Collection Phase provides information on data submission as opposed to grant/project completion so while the Collection phase and grant/project phase may be closely related they are often different. Collection users with Administrative Privileges are encouraged to edit the Collection Phase. The Program Officer as listed in eRA (for NIH funded grants) may also edit this field. Changes must be saved by clicking the Save button at the bottom of the page. This field is sortable alphabetically in ascending or descending order. Collection Phase options include:
- Pre-Enrollment: A grant/project has started, but has not yet enrolled subjects.
- Enrolling: A grant/project has begun enrolling subjects. Data submission is likely ongoing at this point.
- Data Analysis: A grant/project has completed enrolling subjects and has completed all data submissions.
- Funding Completed: A grant/project has reached the project end date.
Collection Title

An editable field with the title of the Collection, which is often the title of the grant associated with the Collection.
Grant

Provides the grant number(s) for the grant(s) associated with the Collection. The field is a hyperlink so clicking on the Grant number will direct the user to the grant information in the NIH Research Portfolio Online Reporting Tools (RePORT) page.
Supporting Documentation

Various documents and materials to enable efficient use of the data by investigators unfamiliar with the project and may include the research protocol, questionnaires, and study manuals.
NIH Research Initiative

NDA Collections may be organized by scientific similarity into NIH Research Initiatives, to facilitate query tool user experience. NIH Research Initiatives map to one or multiple Funding Opportunity Announcements.
Permission Group

Access to shared record-level data in NDA is provisioned at the level of a Permission Group. NDA Permission Groups consist of one or multiple NDA Collections that contain data with the same subject consents.
Planned Enrollment

Number of human subject participants to be enrolled in an NIH-funded clinical research study. The data is provided in competing applications and annual progress reports.
Actual Enrollment

Number of human subjects enrolled in an NIH-funded clinical research study. The data is provided in annual progress reports.
NDA Collection

A virtual container and organization structure for data and associated documentation from one grant or one large project/consortium. It contains tools for tracking data submission and allows investigators to define a wide array of other elements that provide context for the data, including all general information regarding the data and source project, experimental parameters used to collect any event-based data contained in the Collection, methods, and other supporting documentation. They also allow investigators to link underlying data to an NDA Study, defining populations and subpopulations specific to research aims.
Data Use Limitations

Data Use Limitations (DULs) describe the appropriate secondary use of a dataset and are based on the original informed consent of a research participant. NDA only accepts consent-based data use limitations defined by the NIH Office of Science Policy.
Total Subjects Shared

The total number of unique subjects for whom data have been shared and are available for users with permission to access data.

Contact NDA Help Desk

ID	Name	Created Date	Status	Type
1757	Value of Control (VOC) Task	05/19/2021	Approved	fMRI
1758	Emotion Conflict Task	05/19/2021	Approved	fMRI

helpcenter.collection.experiments-tab

Collection - Experiments

The number of Experiments included is displayed in parentheses next to the tab name. You may download all experiments associated with the Collection via the Download button. You may view individual experiments by clicking the Experiment Name and add them to the Filter Cart via the Add to Cart button.

Collection Owners, Program Officers, and users with Submission or Administrative Privileges for the Collection may create or edit an Experiment.

Please note: The creation of an NDA Experiment does not necessarily mean that data collected, according to the defined Experiment, has been submitted or shared.

Frequently Asked Questions

Can an Experiment be associated with more than one Collection?
Yes -see the “Copy” button in the bottom left when viewing an experiment. There are two actions that can be performed via this button:
1. Copy the experiment with intent for modifications.
2. Associate the experiment to the collection. No modifications can be made to the experiment.

Glossary

Experiment Status

An Experiment must be Approved before data using the associated Experiment_ID may be uploaded.
Experiment ID

The ID number automatically generated by NDA which must be included in the appropriate file when uploading data to link the Experiment Definition to the subject record.

Contact NDA Help Desk

Shared Data:

Title	Type	Number of Subjects
Beck Depression Inventory	Clinical Assessments	90
Childhood Trauma Questionnaire	Clinical Assessments	78
Coping Inventory for Stressful Situations (CISS)	Clinical Assessments	90
Current Menstrual State and Menstrual History	Clinical Assessments	91
Demographics Form Short	Clinical Assessments	90
Fagerstrom Test for Nicotine Dependence	Clinical Assessments	90
Hamilton Rating Scale for Depression	Clinical Assessments	90
Image	Imaging	60
Nicotine Craving Questionnaire	Clinical Assessments	82
PROMIS: Patient Reported Outcome Measurement Information System	Clinical Assessments	90
Perceived Stress Scale	Clinical Assessments	90
Quality of Life Enjoyment and Satisfaction Questionnaire	Clinical Assessments	90
Questionnaire of Unpredictability in Childhood	Clinical Assessments	90
Quick Inventory of Depressive Symptomatology	Clinical Assessments	90
Research Subject	Clinical Assessments	90
Rotter's Locus of Control Scale	Clinical Assessments	83
SCID-V Diagnosis	Clinical Assessments	89
SF-36 Health Survey	Clinical Assessments	90
Snaith-Hamilton Pleasure Scale	Clinical Assessments	90
Spectroscopy Form	Imaging	53
Stress and Adversity Inventory	Clinical Assessments	90

helpcenter.collection.shared-data-tab

Collection - Shared Data

This tab provides a quick overview of the Data Structure title, Data Type, and Number of Subjects that are currently Shared for the Collection. The information presented in this tab is automatically generated by NDA and cannot be edited. If no information is visible on this tab, this would indicate the Collection does not have shared data or the data is private.

The shared data is available to other researchers who have permission to access data in the Collection's designated Permission Group(s). Use the Download button to get all shared data from the Collection to the Filter Cart.

Frequently Asked Questions

How will I know if another researcher uses data that I shared through the NIMH Data Archive (NDA)?

To see what data your project have submitted are being used by a study, simply go the Associated Studies tab of your collection. Alternatively, you may review an NDA Study Attribution Report available on the General tab.
Can I get a supplement to share data from a completed research project?

Often it becomes more difficult to organize and format data electronically after the project has been completed and the information needed to create a GUID may not be available; however, you may still contact a program staff member at the appropriate funding institution for more information.
Can I get a supplement to share data from a research project that is still ongoing?

Unlike completed projects where researchers may not have the information needed to create a GUID and/or where the effort needed to organize and format data becomes prohibitive, ongoing projects have more of an opportunity to overcome these challenges. Please contact a program staff member at the appropriate funding institution for more information.

Glossary

Data Structure

A defined organization and group of Data Elements to represent an electronic definition of a measure, assessment, questionnaire, or collection of data points. Data structures that have been defined in the NDA Data Dictionary are available at https://nda.nih.gov/general-query.html?q=query=data-structure
Data Type

A grouping of data by similar characteristics such as Clinical Assessments, Omics, or Neurosignal data.
Shared

The term 'Shared' generally means available to others; however, there are some slightly different meanings based on what is Shared. A Shared NDA Study is viewable and searchable publicly regardless of the user's role or whether the user has an NDA account. A Shared NDA Study does not necessarily mean that data used in the NDA Study have been shared as this is independently determined. Data are shared according the schedule defined in a Collection's Data Expected Tab and/or in accordance with data sharing expectations in the NDA Data Sharing Terms and Conditions. Additionally, Supporting Documentation uploaded to a Collection may be shared independent of whether data are shared.

Contact NDA Help Desk

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Publications

Publications relevant to NDA data are listed below. Most displayed publications have been associated with the grant within Pubmed. Use the "+ New Publication" button to add new publications. Publications relevant/not relevant to data expected are categorized. Relevant publications are then linked to the underlying data by selecting the Create Study link. Study provides the ability to define cohorts, assign subjects, define outcome measures and lists the study type, data analysis and results. Analyzed data and results are expected in this way.

PubMed ID	Study	Title	Journal	Authors	Date	Status
41714875	Create Study	Deep Learning-Based Structural Brain Age Estimation in Bipolar Disorder and Schizophrenia: A Single-Site Pilot Study.	Human brain mapping	Weerasekera, Akila; Zhou, Shuqin; Wang, Chao; Qiu, Zhilang; Stein, Abigail; Ameer, Margaux; Chouinard, Virginie-Anne; Shinn, Ann; Lewandowski, Kathryn E; Murphy, Michael; Halko, Mark; Türközer, Halide Bilge; Öngür, Dost; Du, Fei	February 15, 2026	Not Determined
41519170	Create Study	Widespread cortical thinning and subcortical alterations in mood and psychotic disorders across first-episode and chronic stages.	Journal of affective disorders	Zhou, Shuqin; Weerasekera, Akila; Wang, Chao; Stein, Abigail; Ameer, Margaux; Chouinard, Virginie-Anne; Shinn, Ann; Lewandowski, Kathryn E; Murphy, Michael; Halko, Mark; Türközer, Halide Bilge; Öngür, Dost; Du, Fei	April 15, 2026	Not Determined
41324845	Create Study	Shared and distinct features of common effort-based decision-making paradigms and their relation to brain structure and neuropsychiatric conditions: An integrated narrative review.	Cognitive, affective & behavioral neuroscience	Bogdanov, Mario; Pizzagalli, Diego A	April 1, 2026	Not Determined
41181354	Create Study	Brain dynamics reflecting an intra-network brain state is associated with increased posttraumatic stress symptoms in the early aftermath of trauma.	Nature. Mental health	Sendi, Mohammad Se; Fu, Zening; Harnett, Nathaniel G; van Rooij, Sanne J H; Vergara, Victor; Pizzagalli, Diego A; Daskalakis, Nikolaos P; House, Stacey L; Beaudoin, Francesca L; An, Xinming; Neylan, Thomas C; Clifford, Gari D; Jovanovic, Tanja; Linnstaedt, Sarah D; Germine, Laura T; Bollen, Kenneth A; Rauch, Scott L; Haran, John P; Storrow, Alan B; Lewandowski, Christopher; Musey Jr, Paul I; Hendry, Phyllis L; Sheikh, Sophia; Jones, Christopher W; Punches, Brittany E; Swor, Robert A; Gentile, Nina T; Murty, Vishnu P; Hudak, Lauren A; Pascual, Jose L; Seamon, Mark J; Harris, Erica; Chang, Anna M; Pearson, Claire; Peak, David A; Merchant, Roland C; Domeier, Robert M; Rathlev, Niels K; O'Neil, Brian J; Sergot, Paulina; Sanchez, Leon D; Bruce, Steven E; Sheridan, John F; Harte, Steven E; Kessler, Ronald C; Koenen, Karestan C; McLean, Samuel A; Stevens, Jennifer S; Calhoun, Vince D; Ressler, Kerry J	February 1, 2025	Not Determined
40926089	Create Study	Dopaminergic frontostriatal pathways in major depressive disorder and childhood sexual abuse: a multimodal neuroimaging investigation.	Molecular psychiatry	Borchers, Lauren R; Dan, Rotem; Belleau, Emily L; Kaiser, Roselinde H; Clegg, Rachel; Goer, Franziska; Pechtel, Pia; Beltzer, Miranda; Wooten, Dustin; El Fakhri, Georges; Normandin, Marc D; Pizzagalli, Diego A	January 1, 2026	Not Determined
40852172	Create Study	Prospective Relations between Cortical Thickness and Change in Internalizing Symptoms are Moderated by Chronic Stress Exposure in Adolescents with Depression and Anxiety.	Clinical psychological science : a journal of the Association for Psychological Science	Romer, Adrienne L; Hubbard, Nicholas A; Auerbach, Randy P; Yendiki, Anastasia; Ghosh, Satrajit; Henin, Aude; Hofmann, Stefan G; Gabrieli, John D E; Whitfield-Gabrieli, Susan; Pizzagalli, Diego A	July 27, 2025	Not Determined
40751564	Create Study	Evidence of Disrupted Hippocampal Gray- and White-Matter Development in Adolescent Anxiety Disorders, Independent From Early-Life Stress.	Hippocampus	Pedroza-Sotelo, Karina; Schwarb, Hillary; Auerbach, Randy P; Ghosh, Satrajit S; Henin, Aude; Hofmann, Stefan G; Pizzagalli, Diego A; Yendiki, Anastasia; Whitfield-Gabrieli, Susan; Gabrieli, John D E; Hubbard, Nicholas A	September 1, 2025	Not Determined
40712699	Create Study	Structural Covariance of Early Visual Cortex Is Negatively Associated With Posttraumatic Stress Disorder Symptoms: A Mega-Analysis From the ENIGMA PTSD Working Group.	Biological psychiatry. Cognitive neuroscience and neuroimaging	Harnett, Nathaniel G; Joshi, Soumyaa; Kumar, Poornima; Russell, Courtney; Dillon, Daniel G; Baker, Justin T; Pizzagalli, Diego A; Kaufman, Milissa L; Nickerson, Lisa D; Jahanshad, Neda; Salminen, Lauren E; Thomopoulos, Sophia I; Frijling, Jessie L; Veltman, Dick J; Koch, Saskia B J; Nawijn, Laura; van Zuiden, Mirjam; Zhu, Ye; Li, Gen; Ipser, Jonathan; Zhu, Xi; Ravid, Orren; Zilcha-Mano, Sigal; Lazarov, Amit; Suarez-Jimenez, Benjamin; Sun, Delin; Hussain, Ahmed; Huggins, Ashley A; Jovanovic, Tanja; van Rooij, Sanne J H; Fani, Negar; Hudson, Anna R; Sierk, Anika; Manthey, Antje; Walter, Henrik; van der Wee, Nic J A; van der Werff, Steven J A; Vermeiren, Robert R J M; Říha, Pavel; Lebois, Lauren A M; Rosso, Isabelle M; Olson, Elizabeth A; Liberzon, Israel; Angstadt, Mike; Disner, Seth G; Sponheim, Scott R; Koopowitz, Sheri-Michelle; Hofmann, David; Qi, Rongfeng; Maron-Katz, Adi; Kunch, Austin; Xie, Hong; El-Hage, Wissam; Berg, Hannah; Bruce, Steven E; McLaughlin, Katie A; Peverill, Matthew; Sambrook, Kelly; Ross, Marisa; Herringa, Ryan J; Nitschke, Jack B; Davidson, Richard J; deRoon-Cassini, Terri A; Tomas, Carissa W; Fitzgerald, Jacklynn M; Blackford, Jennifer Urbano; Olatunji, Bunmi O; Nelson, Steven M; Gordon, Evan M; Densmore, Maria; Théberge, Jean; Neufeld, Richard W J; Olff, Miranda; Wang, Li; Stein, Dan J; Neria, Yuval; Stevens, Jennifer S; Mueller, Sven C; Daniels, Judith K; Rektor, Ivan; King, Anthony; Davenport, Nicholas D; Straube, Thomas; Lu, Guangming; Etkin, Amit; Wang, Xin; Quidé, Yann; Lissek, Shmuel; Cisler, Josh; Grupe, Daniel W; Larson, Christine; Feola, Brandee; May, Geoffrey; Abdallah, Chadi G; Lanius, Ruth; Thompson, Paul M; Morey, Rajendra A; Ressler, Kerry J	January 1, 2026	Not Determined
39618324	Create Study	Childhood sexual abuse and lifetime depressive symptoms: the importance of type and timing of childhood emotional maltreatment.	Psychological medicine	Hutson, Lauren M; Dan, Rotem; Brown, Aliza R; Esfand, Shiba M; Ruberto, Valerie; Johns, Emily; Null, Kaylee E; Ohashi, Kyoko; Khan, Alaptagin; Du, Fei; Teicher, Martin H; Pizzagalli, Diego A	November 1, 2024	Not Determined
39603414	Create Study	Social Buffering of Posttraumatic Stress Disorder: Longitudinal Effects and Neural Mediators.	Biological psychiatry. Cognitive neuroscience and neuroimaging	Santos, Justin L C; Harnett, Nathaniel G; van Rooij, Sanne J H; Ely, Timothy D; Jovanovic, Tanja; Lebois, Lauren A M; Beaudoin, Francesca L; An, Xinming; Neylan, Thomas C; Linnstaedt, Sarah D; Germine, Laura T; Bollen, Kenneth A; Rauch, Scott L; Haran, John P; Storrow, Alan B; Lewandowski, Christopher; Musey Jr, Paul I; Hendry, Phyllis L; Sheikh, Sophia; Jones, Christopher W; Punches, Brittany E; Pascual, Jose L; Seamon, Mark J; Harris, Erica; Pearson, Claire; Peak, David A; Merchant, Roland C; Domeier, Robert M; Rathlev, Niels K; O'Neil, Brian J; Sergot, Paulina; Sanchez, Leon D; Bruce, Steven E; Pizzagalli, Diego A; Harte, Steven E; Ressler, Kerry J; Koenen, Karestan C; McLean, Samuel A; Stevens, Jennifer S	May 1, 2025	Not Determined
39420578	Create Study	Brain encoding during perceived control as a prospective predictor of improvement in quality of life.	Social cognitive and affective neuroscience	Dan, Rotem; Brown, Aliza R; Hutson, Lauren; Belleau, Emily L; Esfand, Shiba M; Ruberto, Valerie; Johns, Emily; Null, Kaylee E; Du, Fei; Pizzagalli, Diego A	November 12, 2024	Not Determined
39389310	Create Study	Reward Neurocircuitry Predicts Longitudinal Changes in Alcohol Use Following Trauma Exposure.	Biological psychiatry. Cognitive neuroscience and neuroimaging	Hinojosa, Cecilia A; van Rooij, Sanne J H; Fani, Negar; Ellis, Robyn A; Harnett, Nathaniel G; Lebois, Lauren A M; Ely, Timothy D; Jovanovic, Tanja; Murty, Vishnu P; House, Stacey L; Beaudoin, Francesca L; An, Xinming; Neylan, Thomas C; Clifford, Gari D; Linnstaedt, Sarah D; Germine, Laura T; Rauch, Scott L; Haran, John P; Storrow, Alan B; Lewandowski, Christopher; Musey Jr, Paul I; Hendry, Phyllis L; Sheikh, Sophia; Jones, Christopher W; Punches, Brittany E; Hudak, Lauren A; Pascual, Jose L; Seamon, Mark J; Harris, Erica; Pearson, Claire; Peak, David A; Merchant, Roland C; Domeier, Robert M; Rathlev, Niels K; O'Neil, Brian J; Sergot, Paulina; Bruce, Steven E; Pizzagalli, Diego A; Sheridan, John F; Harte, Steven E; Koenen, Karestan C; Kessler, Ronald C; McLean, Samuel A; Ressler, Kerry J; Stevens, Jennifer S	March 1, 2025	Not Determined
39083325	Create Study	Neighborhood Resources Associated With Psychological Trajectories and Neural Reactivity to Reward After Trauma.	JAMA psychiatry	Webb, E Kate; Stevens, Jennifer S; Ely, Timothy D; Lebois, Lauren A M; van Rooij, Sanne J H; Bruce, Steven E; House, Stacey L; Beaudoin, Francesca L; An, Xinming; Neylan, Thomas C; Clifford, Gari D; Linnstaedt, Sarah D; Germine, Laura T; Bollen, Kenneth A; Rauch, Scott L; Haran, John P; Storrow, Alan B; Lewandowski, Christopher; Musey Jr, Paul I; Hendry, Phyllis L; Sheikh, Sophia; Jones, Christopher W; Punches, Brittany E; Swor, Robert A; Murty, Vishnu P; Hudak, Lauren A; Pascual, Jose L; Seamon, Mark J; Datner, Elizabeth M; Pearson, Claire; Peak, David A; Domeier, Robert M; Rathlev, Niels K; O'Neil, Brian J; Sergot, Paulina; Sanchez, Leon D; Joormann, Jutta; Pizzagalli, Diego A; Harte, Steven E; Kessler, Ronald C; Koenen, Karestan C; Ressler, Kerry J; McLean, Samuel A; Harnett, Nathaniel G	November 1, 2024	Not Determined
37812338	Create Study	Magnetic Resonance Spectroscopy Studies of Brain Energy Metabolism in Schizophrenia: Progression from Prodrome to Chronic Psychosis.	Current psychiatry reports	Stein, Abigail; Zhu, Chenyanwen; Du, Fei; Öngür, Dost	November 1, 2023	Not Relevant
37708432	Create Study	Translational In Vivo Assays in Behavioral Biology.	Annual review of pharmacology and toxicology	Withey, Sarah L; Pizzagalli, Diego A; Bergman, Jack	January 23, 2024	Not Determined
37536568	Create Study	Anhedonia and Delay Discounting: Differing Patterns of Brain-Behavior Relationships in Healthy Control Participants Versus Individuals With Posttraumatic Stress Disorder.	Biological psychiatry. Cognitive neuroscience and neuroimaging	Olson, Elizabeth A; Ahmad, Subul; Granger, Steven J; Ashraf, Aseelah; Pizzagalli, Diego A; Rosso, Isabelle M	January 1, 2024	Not Relevant
37301129	Create Study	Striatal dopamine in anhedonia: A simultaneous [11C]raclopride positron emission tomography and functional magnetic resonance imaging investigation.	Psychiatry research. Neuroimaging	Phillips, Rachel D; Walsh, Erin C; Zürcher, Nicole R; Lalush, David S; Kinard, Jessica L; Tseng, Chieh-En; Cernasov, Paul M; Kan, Delia; Cummings, Kaitlin; Kelley, Lisalynn; Campbell, David; Dillon, Daniel G; Pizzagalli, Diego A; Izquierdo-Garcia, David; Hooker, Jacob M; Smoski, Moria J; Dichter, Gabriel S	August 1, 2023	Not Relevant
36788375	Create Study	Association of default-mode network neurotransmitters and inter-network functional connectivity in first episode psychosis.	Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology	Chen, Xi; Song, Xiaopeng; Öngür, Dost; Du, Fei	April 1, 2023	Not Relevant
36624694	Create Study	Childhood adversities and risk of posttraumatic stress disorder and major depression following a motor vehicle collision in adulthood.	Epidemiology and psychiatric sciences	Ziobrowski, H N; Holt-Gosselin, B; Petukhova, M V; King, A J; Lee, S; House, S L; Beaudoin, F L; An, X; Stevens, J S; Zeng, D; Neylan, T C; Clifford, G D; Linnstaedt, S D; Germine, L T; Bollen, K A; Rauch, S L; Haran, J P; Storrow, A B; Lewandowski, C; Musey, P I; Hendry, P L; Sheikh, S; Jones, C W; Punches, B E; Kurz, M C; Swor, R A; Hudak, L A; Pascual, J L; Seamon, M J; Harris, E; Pearson, C; Merchant, R C; Domeier, R M; Rathlev, N K; O'Neil, B J; Sergot, P; Sanchez, L D; Bruce, S E; Miller, M W; Pietrzak, R H; Joormann, J; Barch, D M; Pizzagalli, D A; Harte, S E; Elliott, J M; Ressler, K J; McLean, S A; Koenen, K C; Kessler, R C	January 10, 2023	Not Relevant
36532372	Create Study	Stress and reward: A multimodal assessment of childhood sexual abuse.	Neurobiology of stress	Pechtel, Pia; Belleau, Emily L; Kaiser, Roselinde H; Whitton, Alexis E; Beltzer, Miranda; Clegg, Rachel; Goer, Franziska; Vitaliano, Gordana; Teicher, Martin H; Pizzagalli, Diego A	November 1, 2022	Not Determined
36044792	Create Study	Resting state brain dynamics: Associations with childhood sexual abuse and major depressive disorder.	NeuroImage. Clinical	Belleau, Emily L; Bolton, Thomas A W; Kaiser, Roselinde H; Clegg, Rachel; Cárdenas, Emilia; Goer, Franziska; Pechtel, Pia; Beltzer, Miranda; Vitaliano, Gordana; Olson, David P; Teicher, Martin H; Pizzagalli, Diego A	January 1, 2022	Not Determined
35775159	Create Study	Toward a Better Understanding of the Mechanisms and Pathophysiology of Anhedonia: Are We Ready for Translation?	The American journal of psychiatry	Pizzagalli, Diego A	July 1, 2022	Not Determined
35471613	Create Study	Effects of modafinil on electroencephalographic microstates in healthy adults.	Psychopharmacology	Linton, Samantha R; Murphy, Michael; Schroder, Hans S; Breiger, Micah; Iturra-Mena, Ann M; Kangas, Brian D; Bergman, Jack; Carlezon Jr, William A; Risbrough, Victoria B; Barnes, Samuel A; Der-Avakian, Andre; Pizzagalli, Diego A	August 1, 2022	Not Relevant
35438797	Create Study	Emerging ecophenotype: reward anticipation is linked to high-risk behaviours after sexual abuse.	Social cognitive and affective neuroscience	Pechtel, Pia; Harris, Jennifer; Karl, Anke; Clunies-Ross, Caroline; Bower, Susie; Moberly, Nicholas J; Pizzagalli, Diego A; Watkins, Edward R	November 2, 2022	Not Relevant
35435644	Create Study	Probabilistic Reinforcement Learning and Anhedonia.	Current topics in behavioral neurosciences	Kangas, Brian D; Der-Avakian, Andre; Pizzagalli, Diego A	January 1, 2022	Not Determined

helpcenter.collection.publications-tab

Collection - Publications

The number of Publications is displayed in parentheses next to the tab name. Clicking on any of the Publication Titles will open the Publication in a new internet browsing tab.

Collection Owners, Program Officers, and users with Submission or Administrative Privileges for the Collection may mark a publication as either Relevant or Not Relevant in the Status column.

Frequently Asked Questions

How can I determine if a publication is relevant?

Publications are considered relevant to a collection when the data shared is directly related to the project or collection.
Where does the NDA get the publications?

PubMed, an online library containing journals, articles, and medical research. Sponsored by NiH and National Library of Medicine (NLM).

Glossary

Create Study

A link to the Create an NDA Study page that can be clicked to start creating an NDA Study with information such as the title, journal and authors automatically populated.
Not Determined Publication

Indicates that the publication has not yet been reviewed and/or marked as Relevant or Not Relevant so it has not been determined whether an NDA Study is expected.
Not Relevant Publication

A publication that is not based on data related to the aims of the grant/project associated with the Collection or not based on any data such as a review article and, therefore, an NDA Study is not expected to be created.
PubMed

PubMed provides citation information for biomedical and life sciences publications and is managed by the U.S. National Institutes of Health's National Library of Medicine.
PubMed ID

The PUBMed ID is the unique ID number for the publication as recorded in the PubMed database.
Relevant Publication

A publication that is based on data related to the aims of the grant/project associated with the Collection and, therefore, an NDA Study is expected to be created.

Contact NDA Help Desk

Data Expected List: Mandatory Data Structures

These data structures are mandatory for your NDA Collection. Please update the Targeted Enrollment number to accurately represent the number of subjects you expect to submit for the entire study.

For NIMH HIV-related research that involves human research participants: Select the dictionary or dictionaries most appropriate for your research. If your research does not require all three data dictionaries, just ignore the ones you do not need. There is no need to delete extra data dictionaries from your NDA Collection. You can adjust the Targeted Enrollment column in the Data Expected tab to “0” for those unnecessary data dictionaries. At least one of the three data dictionaries must have a non-zero value.

Data Expected	Targeted Enrollment	Initial Submission	Subjects Submitted	Initial Share	Subjects Shared	Status
Research Subject and Pedigree	102	07/15/2021	95	11/15/2021	90	Approved

To create your project's Data Expected list, use the "+New Data Expected" to add or request existing structures and to request new Data Structures that are not in the NDA Data Dictionary.

If the Structure you need already exists, locate it and specify your dates and enrollment when adding it to your Data Expected list. If you require changes to the Structure you need, select the indicator stating "No, it requires changes to meet research needs," and upload a file containing your requested changes.

If the structure you need is not yet defined in the Data Dictionary, you can select "Upload Definition" and attach the necessary materials to request its creation.

When selecting the expected dates for your data, make sure to follow the standard Data Sharing Regimen and choose dates within the date ranges that correspond to your project start and end dates.

Please visit the Completing Your Data Expected Tutorial for more information.

Data Expected List: Data Structures per Research Aims

These data structures are specific to your research aims and should list all data structures in which data will be collected and submitted for this NDA Collection. Please update the Targeted Enrollment number to accurately represent the number of subjects you expect to submit for the entire study.

Data Expected	Targeted Enrollment	Initial Submission	Subjects Submitted	Initial Share	Subjects Shared	Status
Perceived Stress Scale	160	07/15/2021	95	11/15/2021	90	Approved
Childhood Trauma Questionnaire	160	07/15/2021	95	11/15/2021	78	Approved
Medical History	160	07/15/2021	96	11/15/2021	91	Approved
Demographics	160	07/15/2021	95	11/15/2021	90	Approved
Spectroscopy	160	07/15/2021	61	11/15/2021	53	Approved
SF36 Health QoL	160	07/15/2021	95	11/15/2021	90	Approved
Structured Clinical Interview for DSM (SCID)	160	07/15/2021	94	11/15/2021	89	Approved
Physical Exam	160	07/15/2021	0	11/15/2021	0	Approved
Beck Depression Inventory	160	07/15/2021	95	11/15/2021	90	Approved
Fagerstrom Test for Nicotine Dependence	160	07/15/2021	95	11/15/2021	90	Approved
PROMIS: Patient Reported Outcome Measurement Information System	160	07/15/2021	95	11/15/2021	90	Approved
Hamilton Rating Scale for Depression	160	07/15/2021	94	11/15/2021	90	Approved
Imaging (Structural, fMRI, DTI, PET, microscopy)	160	07/15/2021	64	11/15/2021	60	Approved
Quick Inventory of Depressive Symptomatology	160	07/15/2021	94	11/15/2021	90	Approved
Quality of Life Enjoyment and Satisfaction Questionnaire	160	07/15/2021	95	11/15/2021	90	Approved
Snaith-Hamilton Pleasure Scale	160	07/15/2021	95	11/15/2021	90	Approved
Blood Sample Collection	160	07/15/2021	0	11/15/2021	0	Approved
Emotional Stroop Task	160	07/15/2021	0	11/15/2021	0	Approved
Longitudinal Interval Evaluation	160	07/15/2021	0	11/15/2021	0	Approved
Nicotine Craving Questionnaire	160	07/15/2021	87	11/15/2021	82	Approved
Coping in Stressful Situations (CISS)	160	07/15/2021	95	11/15/2021	90	Approved
Stress and Adversity Inventory	160	07/15/2021	95	11/15/2021	90	Approved
Locus of Control Questionnaire (LOC)	160	07/15/2021	88	11/15/2021	83	Approved
Questionnaire of Unpredictability in Childhood	160	07/15/2021	95	11/15/2021	90	Approved
Maltreatment and Abuse Chronology of Exposure (MACE)	160	07/15/2021	0	11/15/2021	0	Approved
Value of Control (VOC)	160	07/15/2021	38	11/15/2021	0	Approved

Structure not yet defined

No Status history for this Data Expected has been recorded yet

helpcenter.collection.data-expected-tab

Collection - Data Expected

The Data Expected tab displays the list of all data that NDA expects to receive in association with the Collection as defined by the contributing researcher, as well as the dates for the expected initial upload of the data, and when it is first expected to be shared, or with the research community. Above the primary table of Data Expected, any publications determined to be relevant to the data within the Collection are also displayed - members of the contributing research group can use these to define NDA Studies, connecting those papers to underlying data in NDA.

The tab is used both as a reference for those accessing shared data, providing information on what is expected and when it will be shared, and as the primary tracking mechanism for contributing projects. It is used by both contributing primary researchers, secondary researchers, and NIH Program and Grants Management staff.

Researchers who are starting their project need to update their Data Expected list to include all the Data Structures they are collecting under their grant and set their initial submission and sharing schedule according to the NDA Data Sharing Regimen.

To add existing Data Structures from the Data Dictionary, to request new Data Structure that are not in the Dictionary, or to request changes to existing Data Structures, click "+New Data Expected".

For step-by-step instructions on how to add existing Data Structures, request changes to an existing Structure, or request a new Data Structure, please visit the Completing Your Data Expected Tutorial.

If you are a contributing researcher creating this list for the first time, or making changes to the list as your project progress, please note the following:

Although items you add to the list and changes you make are displayed, they are not committed to the system until you Save the entire page using the "Save" button at the bottom of your screen. Please Save after every change to ensure none of your work is lost.
If you attempt to add a new structure, the title you provide must be unique - if another structure exists with the same name your change will fail.
Adding a new structure to this list is the only way to request the creation of a new Data Dictionary definition.

Frequently Asked Questions

What is an NDA Data Structure?

An NDA Data Structure is comprised of multiple Data Elements to make up an electronic definition of an assessment, measure, questionnaire, etc will have a corresponding Data Structure.
What is the NDA Data Dictionary?

The NDA Data Dictionary is comprised of electronic definitions known as Data Structures.

Glossary

Analyzed Data

Data specific to the primary aims of the research being conducted (e.g. outcome measures, other dependent variables, observations, laboratory results, analyzed images, volumetric data, etc.) including processed images.
Data Item

Items listed on the Data Expected list in the Collection which may be an individual and discrete Data Structure, Data Structure Category, or Data Structure Group.
Data Structure

A defined organization and group of Data Elements to represent an electronic definition of a measure, assessment, questionnaire, or collection of data points. Data structures that have been defined in the NDA Data Dictionary are available at https://nda.nih.gov/general-query.html?q=query=data-structure
Data Structure Category

An NDA term describing the affiliation of a Data Structure to a Category, which may be disease/disorder or diagnosis related (Depression, ADHD, Psychosis), specific to data type (MRI, eye tracking, omics), or type of data (physical exam, IQ).
Data Structure Group

A Data Item listed on the Data Expected tab of a Collection that indicates a group of Data Structures (e.g., ADOS or SCID) for which data may be submitted instead of a specific Data Structure identified by version, module, edition, etc. For example, the ADOS Data Structure Category includes every ADOS Data Structure such as ADOS Module 1, ADOS Module 2, ADOS Module 1 - 2nd Edition, etc. The SCID Data Structure Group includes every SCID Data Structure such as SCID Mania, SCID V Mania, SCID PTSD, SCID-V Diagnosis, and more.
Evaluated Data

A new Data Structure category, Evaluated Data is analyzed data resulting from the use of computational pipelines in the Cloud and can be uploaded directly back to a miNDAR database. Evaluated Data is expected to be listed as a Data Item in the Collection's Data Expected Tab.
Imaging Data

Imaging+ is an NDA term which encompasses all imaging related data including, but not limited to, images (DTI, MRI, PET, Structural, Spectroscopy, etc.) as well as neurosignal data (EEG, fMRI, MEG, EGG, eye tracking, etc.) and Evaluated Data.
Initial Share Date

Initial Submission and Initial Share dates should be populated according to the NDA Data Sharing Terms and Conditions. Any modifications to these will go through the approval processes outlined above. Data will be shared with authorized users upon publication (via an NDA Study) or 1-2 years after the grant end date specified on the first Notice of Award, as defined in the applicable Data Sharing Terms and Conditions.
Initial Submission Date

Initial Submission and Initial Share dates should be populated according to these NDA Data Sharing Terms and Conditions. Any modifications to these will go through the approval processes outlined above. Data for all subjects is not expected on the Initial Submission Date and modifications may be made as necessary based on the project's conduct.
Research Subject and Pedigree

An NDA created Data Structure used to convey basic information about the subject such as demographics, pedigree (links family GUIDs), diagnosis/phenotype, and sample location that are critical to allow for easier querying of shared data.
Submission Cycle

The NDA has two Submission Cycles per year - January 15 and July 15.
Submission Exemption

An interface to notify NDA that data may not be submitted during the upcoming/current submission cycle.

Contact NDA Help Desk

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Associated Studies

Studies that have been defined using data from a Collection are important criteria to determine the value of data shared. The number of subjects column displays the counts from this Collection that are included in a Study, out of the total number of subjects in that study. The Data Use column represents whether or not the study is a primary analysis of the data or a secondary analysis. State indicates whether the study is private or shared with the research community.

Study NameFilter by Study Name	DOIFilter by DOI	AbstractFilter by Abstract	Collection/Study SubjectsFilter by Collection/Study Subjects	Data UsageFilter by Data Usage	StateFilter by State
Brain encoding of perceived control as a prospective predictor of improvement in quality of life	10.15154/mfqb-p594	The perception of control has been strongly related to mental health and well-being. Specifically, the lack of perceived control over events has been associated with learned helplessness and disorders of depression and anxiety. However, it is unknown whether brain activation to control and its protective effect against stress can predict changes in quality of life. Here, we probed the neural underpinnings of controllability. We hypothesized that increased neural responsiveness to control would prospectively predict improvements in life satisfaction and enjoyment and that this relationship would be mediated by perceived stress. Healthy female participants (N=40, ages: 25.9 ± 3.5) completed the Value of Control task in an fMRI scanner. Quality of life and perceived stress were assessed at baseline and 6-month follow-up. An elastic-net algorithm was used to select brain predictors of life satisfaction and enjoyment, and the best predictor was included in a mediation model. Increased brain activation for control was found within the putamen, insula, thalamus, mid-cingulate, dorsolateral prefrontal cortex, motor cortex, and cerebellum. In contrast, increased brain activation for lack of control was found within the posterior cingulate cortex and prefrontal cortices. The right putamen was identified by elastic-net as the best prospective predictor of improvement in quality of life and this association was mediated by a reduction in perceived stress. Our findings suggest that neural responsiveness to control may have utility as a potential marker of quality of life and resilience to adversity.	42/42	Secondary Analysis	Shared

* Data not on individual level

helpcenter.collection.associated-studies-tab

Collection - Associated Studies

Clicking on the Study Title will open the study details in a new internet browser tab. The Abstract is available for viewing, providing the background explanation of the study, as provided by the Collection Owner.

Primary v. Secondary Analysis: The Data Usage column will have one of these two choices. An associated study that is listed as being used for Primary Analysis indicates at least some and potentially all of the data used was originally collected by the creator of the NDA Study. Secondary Analysis indicates the Study owner was not involved in the collection of data, and may be used as supporting data.

Private v. Shared State: Studies that remain private indicate the associated study is only available to users who are able to access the collection. A shared study is accessible to the general public.

Frequently Asked Questions

How do I associate a study to my collection?

Studies are associated to the Collection automatically when the data is defined in the Study.

Glossary

Associated Studies Tab

A tab in a Collection that lists the NDA Studies that have been created using data from that Collection including both Primary and Secondary Analysis NDA Studies.

Contact NDA Help Desk

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