NIMH Data Archive - Data

Genomics

Neuroimaging

Phenotype¹

New Trial
Clinical Trial

¹ Numbers reported are subjects by age

New Project
Grant/Project Number

Format should be in the following format: Activity Code, Institute Abbreviation, and Serial Number. Grant Type, Support Year, and Suffix should be excluded. For example, grant 1R01MH123456-01A1 should be entered R01MH123456

Collection - Use Existing Experiment

To associate an experiment to the current collection, just select an axperiment from the table below then click the associate experiment button to persist your changes (saving the collection is not required). Note that once an experiment has been associated to two or more collections, the experiment will not longer be editable.

The table search feature is case insensitive and targets the experiment id, experiment name and experiment type columns. The experiment id is searched only when the search term entered is a number, and filtered using a startsWith comparison. When the search term is not numeric the experiment name is used to filter the results.

Select	Experiment Id	Experiment Name	Experiment Type	Created On

24	HI-NGS_R1	Omics	02/16/2011
475	MB1-10 (CHOP)	Omics	06/07/2016
490	Discovery and CRISPR validation of genetic factors associated with antipsychotic-induced weight gain and cardiometabolic risk	Omics	07/07/2016
501	PharmacoBOLD Resting State	fMRI	07/27/2016
506	PVPREF	Omics	08/05/2016
509	ABC-CT Resting v2	EEG	08/18/2016
13	Comparison of FI expression in Autistic and Neurotypical Homo Sapiens	Omics	12/28/2010
18	AGRE/Broad Affymetrix 5.0 Genotype Experiment	Omics	01/06/2011
22	Stitching PCR Sequencing	Omics	02/14/2011
26	ASD_Methylation	Omics	03/01/2011
29	Microarray family 03 (father, mother, sibling)	Omics	03/24/2011
37	Standard paired-end sequencing of BCRs	Omics	04/19/2011
38	Illumina Mate-Pair BCR sequencing	Omics	04/19/2011
39	Custom Jumping Libraries	Omics	04/19/2011
40	Custom CapBP	Omics	04/19/2011
41	Immunofluorescence	Omics	05/11/2011
43	Autism brain sample genotyping, Illumina	Omics	05/16/2011
47	ARRA Autism Sequencing Collaboration at Baylor. SOLiD 4 System	Omics	08/01/2011
53	AGRE Omni1-quad	Omics	10/11/2011
59	AGP genotyping	Omics	04/03/2012
60	Ultradeep 454 sequencing of synaptic genes from postmortem cerebella of individuals with ASD and neurotypical controls	Omics	06/23/2012
63	Microemulsion PCR and Targeted Resequencing for Variant Detection in ASD	Omics	07/20/2012
76	Whole Genome Sequencing in Autism Families	Omics	01/03/2013
519	Resting	fMRI	11/08/2016
90	Genotyped IAN Samples	Omics	07/09/2013
91	NJLAGS Axiom Genotyping Array	Omics	07/16/2013
93	AGP genotyping (CNV)	Omics	09/06/2013
106	Longitudinal Sleep Study. H20 200. Channel set 2	EEG	11/07/2013
107	Longitudinal Sleep Study. H20 200. Channel set 3	EEG	11/07/2013
108	Longitudinal Sleep Study. AURA 200	EEG	11/07/2013
105	Longitudinal Sleep Study. H20 200. Channel set 1	EEG	11/07/2013
109	Longitudinal Sleep Study. AURA 400	EEG	11/07/2013
116	Gene Expression Analysis WG-6	Omics	01/07/2014
131	Jeste Lab UCLA ACEii: Charlie Brown and Sesame Street - Project 1	Eye Tracking	02/27/2014
132	Jeste Lab UCLA ACEii: Animacy - Project 1	Eye Tracking	02/27/2014
133	Jeste Lab UCLA ACEii: Mom Stranger - Project 2	Eye Tracking	02/27/2014
134	Jeste Lab UCLA ACEii: Face Emotion - Project 3	Eye Tracking	02/27/2014
145	AGRE/FMR1_Illumina.JHU	Omics	04/14/2014
146	AGRE/MECP2_Sanger.JHU	Omics	04/14/2014
147	AGRE/MECP2_Junior.JHU	Omics	04/14/2014
151	Candidate Gene Identification in familial Autism	Omics	06/09/2014
152	NJLAGS Whole Genome Sequencing	Omics	07/01/2014
154	Math Autism Study - Vinod Menon	fMRI	07/15/2014
155	Resting	fMRI	07/25/2014
156	Speech	fMRI	07/25/2014
159	Emotion	fMRI	07/25/2014
160	syllable contrast	EEG	07/29/2014
167	School-age naturalistic stimuli	Eye Tracking	09/19/2014
44	AGRE/Broad Affymetrix 5.0 Genotype Experiment	Omics	06/27/2011
45	Exome Sequencing of 20 Sporadic Cases of Autism Spectrum Disorder	Omics	07/15/2011

Collection - Add Experiment

Add Supporting Documentation

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URL:

To add an existing Data Structure, enter its title in the search bar. If you need to request changes, select the indicator "No, it requires changes to meet research needs" after selecting the Structure, and upload the file with the request changes specific to the selected Data Structure. Your file should follow the Request Changes Procedure. If the Data Structure does not exist, select "Request New Data Structure" and upload the appropriate zip file.

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The CHARGE Study: Childhood Autism Risks From Genetics and the Environment #2066

General
Experiments (0)
Shared Data
Publications (150)
Data Expected (16)
Associated Studies (6)

Collection Title	Collection Investigators	Collection Description
Collection Title:	The CHARGE Study: Childhood Autism Risks From Genetics and the Environment
Collection Investigators:	Irva Hertz-Picciotto
Collection Description:	Few rigorous epidemiologic studies have addressed the environmental causes and biologic underpinnings of autism spectrum disorder (ASD). The CHARGE (CHildhood Autism Risks from Genetics and Environment) Study is a large, population-based case-control investigation of environmental risk factors, broadly defined, in relation to ASD and developmental delay without ASD symptoms, with referents from the general population.Fieldwork began In 2003, and by now CHARGE has published widely on exposures such as air pollution,mercury, flame retardants, maternal nutritional status in the peri-conception, untreated fever during pregnancy,mitochondrial dysfunction, candidate genes, a wide array of functional immune markers in both the child and the mother, and maternal metabolic conditions including obesity and diabetes. This last finding is notable, given the epidemic of obesity and type 2 diabetes that has occurred in parallel with the steady rise in ASD over the last few decades. Moreover, an emerging literature implicates several endocrine disrupting chemicals as contributing to obesity and metabolic dysregulation, including hyper insulinemia, and to neurodevelopmental disorders as well. This project therefore builds upon these observations in several ways.First, obesity and type 2 or gestational diabetes will be examined in a larger sample, and glucose challenge test (GCT) results for the first time, to determine associations not only with development of ASD and intellectual impairment in the children, but also with specific speech and language delays, behavioral phenotypes such as attention deficits or hyperactivity, and gene expression. Second, these maternal metabolic conditions will be evaluated for associations with markers of both metabolic and immune dysregulation to be measured in neonatal blood spots. Third, the predictive value of neonatal bloodspot markers for a later diagnosis of ASD or other child developmental and behavioral outcomes will be assessed. Fourth, the maternal metabolic conditions will be analyzed for potential links with upstream exposures to phthalates and antibacterial compounds, ubiquitous chemicals in common household products. Finally, this project will examine how gene variants that play a role in biochemical pathways relevant to the processes under study may influence susceptibility of the mother, the neonate or the child. To ensure adequate power for this analysis of gene-environment interaction, the sample size will be increased to 2400 children. This project addresses several goals set by the NIH Interagency Autism Coordinating Committee: 1) to discover environmental factors contributing to ASD, particularly in the prenatal period, 2) to understand biological mechanisms for ASD risk,including gene-by-environment interactions, and 3) to identify children at risk for ASD at earlier time points.Results of this detailed inquiry into early exposures, maternal pathophysiology and prognostic markers in the newborn will set the stage for developing prevention strategies.
Data Repository:	NIMH Data Archive
Permission Group:
Collection Creation Date:	10/30/2013
Collection Phase:	Funding Completed
Collection Sub-Phase:	Close Out
Blinded Clinical Trial:	No
Total Funded Amount:	$4,624,873.00
Subjects Shared:	713
Collection DOI:	10.15154/3vtt-6417

{"values":[]}

{"values":[["Not Defined",41],["Autism Spectrum Affected",18],["Autism Spectrum Severely Affected",105]]}

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Funding Sources:

Funding Source Name	Funding Source URL
NIH - Extramural	None

Supporting Documentation:

File Name	File Type	Description	Audience
QA-notification.txt	Other	Quality Assurance Notification	Qualified Researchers

Grant Information:

Project Number	Title	Start Date	Original End Date	End Date	Planned Enrollment	Actual Enrollment	Organization	Funds Obligated
R01ES015359-01	The Charge Study: Childhood Autism Risks from Genetics and the Environment	02/08/2007	01/31/2012	01/31/2012	5608	5501	UNIVERSITY OF CALIFORNIA AT DAVIS	$2,146,125.00
R01ES015359-06	THE CHARGE STUDY: CHILDHOOD AUTISM RISKS FROM GENETICS AND THE ENVIRONMENT	08/19/2013	06/30/2018	06/30/2018	7900	7874	UNIVERSITY OF CALIFORNIA AT DAVIS	$2,478,748.00

Clinical Trials:

helpcenter.collection.general-tab

Collection - General Tab

Fields available for edit on the top portion of the page include:

Collection Title
Investigators
Collection Description
Collection Phase
Funding Source
Clinical Trials

Collection Phase: The current status of a research project submitting data to an NDA Collection, based on the timing of the award and/or the data that have been submitted.

Pre-Enrollment: The default entry made when the NDA Collection is created.
Enrolling: Data have been submitted to the NDA Collection or the NDA Data Expected initial submission date has been reached for at least one data structure category in the NDA Collection.
Data Analysis: Subject level data collection for the research project is completed and has been submitted to the NDA Collection. The NDA Collection owner or the NDA Help Desk may set this phase when they’ve confirmed data submission is complete and submitted subject counts match at least 90% of the target enrollment numbers in the NDA Data Expected. Data submission reminders will be turned off for the NDA Collection.
Funding Completed: The NIH grant award (or awards) associated with the NDA Collection has reached its end date. NDA Collections in Funding Completed phase are assigned a subphase to indicate the status of data submission.
- The Data Expected Subphase indicates that NDA expects more data will be submitted
- The Closeout Subphase indicates the data submission is complete.
- The Sharing Not Met Subphase indicates that data submission was not completed as expected.

Blinded Clinical Trial Status:

This status is set by a Collection Owner and indicates the research project is a double blinded clinical trial. When selected, the public view of Data Expected will show the Data Expected items and the Submission Dates, but the targeted enrollment and subjects submitted counts will not be displayed.
Targeted enrollment and subjects submitted counts are visible only to NDA Administrators and to the NDA Collection or as the NDA Collection Owner.
When an NDA Collection that is flagged Blinded Clinical Trial reaches the maximum data sharing date for that Data Repository (see https://nda.nih.gov/nda/sharing-regimen.html), the embargo on Data Expected information is released.

Funding Source

The organization(s) responsible for providing the funding is listed here.

Supporting Documentation

Users with Submission privileges, as well as Collection Owners, Program Officers, and those with Administrator privileges, may upload and attach supporting documentation. By default, supporting documentation is shared to the general public, however, the option is also available to limit this information to qualified researchers only.

Grant Information

Identifiable details are displayed about the Project of which the Collection was derived from. You may click in the Project Number to view a full report of the Project captured by the NIH.

Clinical Trials

Any data that is collected to support or further the research of clinical studies will be available here. Collection Owners and those with Administrator privileges may add new clinical trials.

Frequently Asked Questions

How does the NIMH Data Archive (NDA) determine which Permission Group data are submitted into?

During Collection creation, NDA staff determine the appropriate Permission Group based on the type of data to be submitted, the type of access that will be available to data access users, and the information provided by the Program Officer during grant award.
How do I know when a NDA Collection has been created?

When a Collection is created by NDA staff, an email notification will automatically be sent to the PI(s) of the grant(s) associated with the Collection to notify them.
Is a single grant number ever associated with more than one Collection?

The NDA system does not allow for a single grant to be associated with more than one Collection; therefore, a single grant will not be listed in the Grant Information section of a Collection for more than one Collection.
Why is there sometimes more than one grant included in a Collection?

In general, each Collection is associated with only one grant; however, multiple grants may be associated if the grant has multiple competing segments for the same grant number or if multiple different grants are all working on the same project and it makes sense to hold the data in one Collection (e.g., Cooperative Agreements).

Glossary

Administrator Privilege

A privilege provided to a user associated with an NDA Collection or NDA Study whereby that user can perform a full range of actions including providing privileges to other users.
Collection Owner

Generally, the Collection Owner is the contact PI listed on a grant. Only one NDA user is listed as the Collection owner. Most automated emails are primarily sent to the Collection Owner.
Collection Phase
The Collection Phase provides information on data submission as opposed to grant/project completion so while the Collection phase and grant/project phase may be closely related they are often different. Collection users with Administrative Privileges are encouraged to edit the Collection Phase. The Program Officer as listed in eRA (for NIH funded grants) may also edit this field. Changes must be saved by clicking the Save button at the bottom of the page. This field is sortable alphabetically in ascending or descending order. Collection Phase options include:
- Pre-Enrollment: A grant/project has started, but has not yet enrolled subjects.
- Enrolling: A grant/project has begun enrolling subjects. Data submission is likely ongoing at this point.
- Data Analysis: A grant/project has completed enrolling subjects and has completed all data submissions.
- Funding Completed: A grant/project has reached the project end date.
Collection Title

An editable field with the title of the Collection, which is often the title of the grant associated with the Collection.
Grant

Provides the grant number(s) for the grant(s) associated with the Collection. The field is a hyperlink so clicking on the Grant number will direct the user to the grant information in the NIH Research Portfolio Online Reporting Tools (RePORT) page.
Supporting Documentation

Various documents and materials to enable efficient use of the data by investigators unfamiliar with the project and may include the research protocol, questionnaires, and study manuals.
NIH Research Initiative

NDA Collections may be organized by scientific similarity into NIH Research Initiatives, to facilitate query tool user experience. NIH Research Initiatives map to one or multiple Funding Opportunity Announcements.
Permission Group

Access to shared record-level data in NDA is provisioned at the level of a Permission Group. NDA Permission Groups consist of one or multiple NDA Collections that contain data with the same subject consents.
Planned Enrollment

Number of human subject participants to be enrolled in an NIH-funded clinical research study. The data is provided in competing applications and annual progress reports.
Actual Enrollment

Number of human subjects enrolled in an NIH-funded clinical research study. The data is provided in annual progress reports.
NDA Collection

A virtual container and organization structure for data and associated documentation from one grant or one large project/consortium. It contains tools for tracking data submission and allows investigators to define a wide array of other elements that provide context for the data, including all general information regarding the data and source project, experimental parameters used to collect any event-based data contained in the Collection, methods, and other supporting documentation. They also allow investigators to link underlying data to an NDA Study, defining populations and subpopulations specific to research aims.
Data Use Limitations

Data Use Limitations (DULs) describe the appropriate secondary use of a dataset and are based on the original informed consent of a research participant. NDA only accepts consent-based data use limitations defined by the NIH Office of Science Policy.
Total Subjects Shared

The total number of unique subjects for whom data have been shared and are available for users with permission to access data.

Contact NDA Help Desk

ID	Name	Created Date	Status	Type
No records found.

helpcenter.collection.experiments-tab

Collection - Experiments

The number of Experiments included is displayed in parentheses next to the tab name. You may download all experiments associated with the Collection via the Download button. You may view individual experiments by clicking the Experiment Name and add them to the Filter Cart via the Add to Cart button.

Collection Owners, Program Officers, and users with Submission or Administrative Privileges for the Collection may create or edit an Experiment.

Please note: The creation of an NDA Experiment does not necessarily mean that data collected, according to the defined Experiment, has been submitted or shared.

Frequently Asked Questions

Can an Experiment be associated with more than one Collection?
Yes -see the “Copy” button in the bottom left when viewing an experiment. There are two actions that can be performed via this button:
1. Copy the experiment with intent for modifications.
2. Associate the experiment to the collection. No modifications can be made to the experiment.

Glossary

Experiment Status

An Experiment must be Approved before data using the associated Experiment_ID may be uploaded.
Experiment ID

The ID number automatically generated by NDA which must be included in the appropriate file when uploading data to link the Experiment Definition to the subject record.

Contact NDA Help Desk

Shared Data:

Title	Type	Number of Subjects
Aberrant Behavior Checklist (ABC) - Community	Clinical Assessments	655
Autism Diagnostic Interview, Revised (ADI-R)	Clinical Assessments	444
Autism Diagnostic Observation Schedule (ADOS) - Module 1 (2007)	Clinical Assessments	64
Autism Diagnostic Observation Schedule (ADOS) - Module 2 (2007)	Clinical Assessments	42
Autism Diagnostic Observation Schedule (ADOS)- Module 3 (2007)	Clinical Assessments	5
Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2) - Module 1	Clinical Assessments	147
Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2) - Module 2	Clinical Assessments	108
Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2) - Module 3	Clinical Assessments	9
CHARGE Physical Exam	Clinical Assessments	408
Demographics	Clinical Assessments	655
Early Development Questionnaire	Clinical Assessments	608
Gastrointestinal History	Clinical Assessments	660
Mullen Scales of Early Learning	Clinical Assessments	654
Parent Chemical or Substance Exposure	Clinical Assessments	639
Research Subject	Clinical Assessments	654
Sleep History	Clinical Assessments	658
Social Communication Questionnaire (SCQ) - Lifetime	Clinical Assessments	279
Vineland I	Clinical Assessments	705

helpcenter.collection.shared-data-tab

Collection - Shared Data

This tab provides a quick overview of the Data Structure title, Data Type, and Number of Subjects that are currently Shared for the Collection. The information presented in this tab is automatically generated by NDA and cannot be edited. If no information is visible on this tab, this would indicate the Collection does not have shared data or the data is private.

The shared data is available to other researchers who have permission to access data in the Collection's designated Permission Group(s). Use the Download button to get all shared data from the Collection to the Filter Cart.

Frequently Asked Questions

How will I know if another researcher uses data that I shared through the NIMH Data Archive (NDA)?

To see what data your project have submitted are being used by a study, simply go the Associated Studies tab of your collection. Alternatively, you may review an NDA Study Attribution Report available on the General tab.
Can I get a supplement to share data from a completed research project?

Often it becomes more difficult to organize and format data electronically after the project has been completed and the information needed to create a GUID may not be available; however, you may still contact a program staff member at the appropriate funding institution for more information.
Can I get a supplement to share data from a research project that is still ongoing?

Unlike completed projects where researchers may not have the information needed to create a GUID and/or where the effort needed to organize and format data becomes prohibitive, ongoing projects have more of an opportunity to overcome these challenges. Please contact a program staff member at the appropriate funding institution for more information.

Glossary

Data Structure

A defined organization and group of Data Elements to represent an electronic definition of a measure, assessment, questionnaire, or collection of data points. Data structures that have been defined in the NDA Data Dictionary are available at https://nda.nih.gov/general-query.html?q=query=data-structure
Data Type

A grouping of data by similar characteristics such as Clinical Assessments, Omics, or Neurosignal data.
Shared

The term 'Shared' generally means available to others; however, there are some slightly different meanings based on what is Shared. A Shared NDA Study is viewable and searchable publicly regardless of the user's role or whether the user has an NDA account. A Shared NDA Study does not necessarily mean that data used in the NDA Study have been shared as this is independently determined. Data are shared according the schedule defined in a Collection's Data Expected Tab and/or in accordance with data sharing expectations in the NDA Data Sharing Terms and Conditions. Additionally, Supporting Documentation uploaded to a Collection may be shared independent of whether data are shared.

Contact NDA Help Desk

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Publications

Publications relevant to NDA data are listed below. Most displayed publications have been associated with the grant within Pubmed. Use the "+ New Publication" button to add new publications. Publications relevant/not relevant to data expected are categorized. Relevant publications are then linked to the underlying data by selecting the Create Study link. Study provides the ability to define cohorts, assign subjects, define outcome measures and lists the study type, data analysis and results. Analyzed data and results are expected in this way.

PubMed ID	Study	Title	Journal	Authors	Date	Status
40820563	Create Study	Trajectory of Irritability in Autistic and Typically Developing Youth From Early Childhood to Adolescence.	Autism research : official journal of the International Society for Autism Research	Calub, Catrina A; Iosif, Ana-Maria; Hertz-Picciotto, Irva; Schweitzer, Julie B	October 1, 2025	Not Determined
40724214	Create Study	Pet Flea and Tick Control Exposure During Pregnancy and Early Life Associated with Decreased Cognitive and Adaptive Behaviors in Children with Developmental Delay and Autism Spectrum Disorder.	International journal of environmental research and public health	Goodrich, Amanda J; Tancredi, Daniel J; Ludeña, Yunin J; Roudneva, Ekaterina; Schmidt, Rebecca J; Hertz-Picciotto, Irva; Bennett, Deborah H	July 19, 2025	Not Determined
40676375	Create Study	Predicting later ADHD presentation types from early childhood autism and intellectual disability.	European child & adolescent psychiatry	Ren, Yunyi; Mlodnicka, Agnieszka; Calub, Catrina Andaya; Hertz-Picciotto, Irva; Schweitzer, Julie B	December 1, 2025	Not Determined
40089117	Create Study	Child Opportunity Index at birth and asthma with recurrent exacerbations in the US ECHO program.	The Journal of allergy and clinical immunology	Miller, Rachel L; Schuh, Holly; Chandran, Aruna; Habre, Rima; Angal, Jyoti; Aris, Izzuddin M; Aschner, Judy L; Bendixsen, Casper G; Blossom, Jeffrey; Bosquet-Enlow, Michelle; Breton, Carrie V; Camargo Jr, Carlos A; Carroll, Kecia N; Commodore, Sarah; Croen, Lisa A; Dabelea, Dana M; Deoni, Sean C L; Ferrara, Assiamira; Fry, Rebecca C; Ganiban, Jody M; Geiger, Sarah D; Gern, James E; Gilliland, Frank D; Gogcu, Semsa; Gold, Diane R; Hare, Marion E; Harte, Robyn N; Hartert, Tina V; Hertz-Picciotto, Irva; Hipwell, Alison E; Jackson, Daniel J; Karagas, Margaret K; Khurana Hershey, Gurjit K; Kim, Haejin; Litonjua, Augusto A; Marsit, Carmen J; McEvoy, Cynthia T; Mendonça, Eneida A; Moore, Paul E; Nguyen, Anh P; Nkoy, Flory L; O'Connor, Thomas G; Oken, Emily; Ownby, Dennis R; Perzanowski, Matthew; Rivera-Spoljaric, Katherine; Sathyanarayana, Sheela; Singh, Anne Marie; Stanford, Joseph B; Stroustrup, Annemarie; Towe-Goodman, Nissa; Wang, Veronica A; Woodruff, Tracey J; Wright, Robert O; Wright, Rosalind J; Zanobetti, Antonella; Zoratti, Edward M; Johnson, Christine C; ECHO Cohort Consortium	September 1, 2025	Not Determined
39738617	Create Study	Metabolomics of mothers of children with autism, idiopathic developmental delay, and Down syndrome.	Scientific reports	Parenti, Mariana; Shoff, Shannon; Sotelo-Orozco, Jennie; Hertz-Picciotto, Irva; Slupsky, Carolyn M	December 30, 2024	Not Determined
39694434	Create Study	Professionally and non-professionally applied household insecticides during pregnancy and early life and their associations with autism spectrum disorder and developmental delay in the CHARGE case-control study.	Environmental research	Goodrich, Amanda J; Tancredi, Daniel J; Ludeña, Yunin J; Bennett, Deborah H; Hertz-Picciotto, Irva; Schmidt, Rebecca J	February 15, 2025	Not Determined
38739245	Create Study	The Association Between Gastrointestinal Issues and Psychometric Scores in Children with Autism Spectrum Disorder, Developmental Delays, Down Syndrome, and Typical Development.	Journal of autism and developmental disorders	Sotelo-Orozco, Jennie; Hertz-Picciotto, Irva	July 1, 2025	Not Determined
38692176	Create Study	Early childhood exposures to phthalates in association with attention-deficit/hyperactivity disorder behaviors in middle childhood and adolescence in the ReCHARGE study.	International journal of hygiene and environmental health	Oh, Jiwon; Schweitzer, Julie B; Buckley, Jessie P; Upadhyaya, Sudhi; Kannan, Kurunthachalam; Herbstman, Julie B; Ghassabian, Akhgar; Schmidt, Rebecca J; Hertz-Picciotto, Irva; Bennett, Deborah H; Environmental influences on Child Health Outcomes	June 1, 2024	Not Determined
38574983	Create Study	Pre-pregnancy ozone and ultrafine particulate matter exposure during second year of life associated with decreased cognitive and adaptive functioning at aged 2-5 years.	Environmental research	Goodrich, Amanda J; Kleeman, Michael J; Tancredi, Daniel J; Ludeña, Yunin J; Bennett, Deborah H; Hertz-Picciotto, Irva; Schmidt, Rebecca J	July 1, 2024	Not Determined
38020477	Create Study	Ex vivo exposure to polybrominated diphenyl ether (PBDE) selectively affects the immune response in autistic children.	Brain, behavior, & immunity - health	Akintunde, Marjannie Eloi; Lin, Yan-Ping; Krakowiak, Paula; Pessah, Isaac N; Hertz-Picciotto, Irva; Puschner, Birgit; Ashwood, Paul; Van de Water, Judy	December 1, 2023	Not Determined
37956751	Create Study	Ultrafine particulate matter exposure during second year of life, but not before, associated with increased risk of autism spectrum disorder in BKMR mixtures model of multiple air pollutants.	Environmental research	Goodrich, Amanda J; Kleeman, Michael J; Tancredi, Daniel J; Ludeña, Yunin J; Bennett, Deborah H; Hertz-Picciotto, Irva; Schmidt, Rebecca J	February 1, 2024	Not Determined
37623848	Create Study	Assessing Repeated Urinary Proline Betaine Measures as a Biomarker of Usual Citrus Intake during Pregnancy: Sources of Within-Person Variation and Correlation with Reported Intake.	Metabolites	French, Caitlin D; Arnold, Charles D; Taha, Ameer Y; Engle-Stone, Reina; Schmidt, Rebecca J; Hertz-Picciotto, Irva; Slupsky, Carolyn M	August 2, 2023	Not Determined
37004853	Create Study	Parental occupational exposure to solvents and autism spectrum disorder: An exploratory look at gene-environment interactions.	Environmental research	McCanlies, Erin C; Gu, Ja Kook; Kashon, Michael; Yucesoy, Berran; Ma, Claudia C; Sanderson, Wayne T; Kim, Kyoungmi; Ludeña-Rodriguez, Yunin J; Hertz-Picciotto, Irva	July 1, 2023	Not Determined
36973347	Create Study	Altered behavior, brain structure, and neurometabolites in a rat model of autism-specific maternal autoantibody exposure.	Molecular psychiatry	Bruce, Matthew R; Couch, Amalie C M; Grant, Simone; McLellan, Janna; Ku, Katherine; Chang, Christina; Bachman, Angelica; Matson, Matthew; Berman, Robert F; Maddock, Richard J; Rowland, Douglas; Kim, Eugene; Ponzini, Matthew D; Harvey, Danielle; Taylor, Sandra L; Vernon, Anthony C; Bauman, Melissa D; Van de Water, Judy	May 1, 2023	Not Determined
36830973	Create Study	Preliminary Findings of Elevated Inflammatory Plasma Cytokines in Children with Autism Who Have Co-Morbid Gastrointestinal Symptoms.	Biomedicines	Ashwood, Paul	February 2, 2023	Not Determined
36144233	Create Study	Maternal Serum and Placental Metabolomes in Association with Prenatal Phthalate Exposure and Neurodevelopmental Outcomes in the MARBLES Cohort.	Metabolites	Parenti, Mariana; Schmidt, Rebecca J; Ozonoff, Sally; Shin, Hyeong-Moo; Tancredi, Daniel J; Krakowiak, Paula; Hertz-Picciotto, Irva; Walker, Cheryl K; Slupsky, Carolyn M	September 2, 2022	Not Determined
35943360	Create Study	Pilot Study of Maternal Autoantibody-Related Autism.	Journal of developmental and behavioral pediatrics : JDBP	Angkustsiri, Kathleen; Fussell, Jill J; Bennett, Amanda; Schauer, Joseph; Ramirez-Celis, Alexandra; Hansen, Robin L; Van de Water, Judy	October 1, 2022	Not Determined
35270242	Create Study	Selecting External Controls for Internal Cases Using Stratification Score Matching Methods.	International journal of environmental research and public health	Busgang, Stefanie A; Waller, Lance A; Colicino, Elena; D'Agostino Jr, Ralph; Hertz-Picciotto, Irva; Gennings, Chris	February 23, 2022	Not Determined
35085933	Create Study	Environmental exposures to pesticides, phthalates, phenols and trace elements are associated with neurodevelopment in the CHARGE study.	Environment international	Bennett, Deborah H; Busgang, Stefanie A; Kannan, Kurunthachalam; Parsons, Patrick J; Takazawa, Mari; Palmer, Christopher D; Schmidt, Rebecca J; Doucette, John T; Schweitzer, Julie B; Gennings, Chris; Hertz-Picciotto, Irva	March 1, 2022	Not Determined
34808292	Create Study	Neonatal chemokine markers predict subsequent diagnosis of autism spectrum disorder and delayed development.	Brain, behavior, and immunity	Kim, Danielle Hj; Krakowiak, Paula; Meltzer, Amory; Hertz-Picciotto, Irva; Van de Water, Judy	February 1, 2022	Not Determined
34561347	Create Study	The Role of Childhood Asthma in Obesity Development: A Nationwide US Multicohort Study.	Epidemiology (Cambridge, Mass.)	Stratakis, Nikos; Garcia, Erika; Chandran, Aruna; Hsu, Tingju; Alshawabkeh, Akram; Aris, Izzuddin M; Aschner, Judy L; Breton, Carrie; Burbank, Allison; Camargo Jr, Carlos A; Carroll, Kecia N; Chen, Zhanghua; Claud, Erika C; Dabelea, Dana; Dunlop, Anne L; Elliott, Amy J; Ferrara, Assiamira; Ganiban, Jody M; Gern, James E; Gold, Diane R; Gower, William A; Hertz-Picciotto, Irva; Karagas, Margaret R; Karr, Catherine J; Lester, Barry; Leve, Leslie D; Litonjua, Augusto A; Ludena, Yunin; McEvoy, Cindy T; Miller, Rachel L; Mueller, Noel T; O'Connor, Thomas G; Oken, Emily; O'Shea, T Michael; Perera, Frederica; Stanford, Joseph B; Rivera-Spoljaric, Katherine; Rundle, Andrew; Trasande, Leonardo; Wright, Rosalind J; Zhang, Yue; Zhu, Yeyi; Berhane, Kiros; Gilliland, Frank; Chatzi, Lida; on behalf of program collaborators for Environmental Influences on Child Health Outcomes	January 1, 2022	Not Determined
34307452	Create Study	A Comparison of Serum and Plasma Blood Collection Tubes for the Integration of Epidemiological and Metabolomics Data.	Frontiers in molecular biosciences	Sotelo-Orozco, Jennie; Chen, Shin-Yu; Hertz-Picciotto, Irva; Slupsky, Carolyn M	January 1, 2021	Not Determined
34290368	Create Study	Sexually dimorphic neuroanatomical differences relate to ASD-relevant behavioral outcomes in a maternal autoantibody mouse model.	Molecular psychiatry	Bruce, Matthew R; Jones, Karen L; Vernon, Anthony C; Silverman, Jill L; Crawley, Jacqueline N; Ellegood, Jacob; Lerch, Jason P; Van de Water, Judy	December 1, 2021	Not Determined
33750431	Create Study	Stable DNMT3L overexpression in SH-SY5Y neurons recreates a facet of the genome-wide Down syndrome DNA methylation signature.	Epigenetics & chromatin	Laufer, Benjamin I; Gomez, J Antonio; Jianu, Julia M; LaSalle, Janine M	March 9, 2021	Not Determined
33483694	Create Study	Risk assessment analysis for maternal autoantibody-related autism (MAR-ASD): a subtype of autism.	Molecular psychiatry	Ramirez-Celis, Alexandra; Becker, Martin; Nuño, Miriam; Schauer, Joseph; Aghaeepour, Nima; Van de Water, Judy	May 1, 2021	Not Determined

helpcenter.collection.publications-tab

Collection - Publications

The number of Publications is displayed in parentheses next to the tab name. Clicking on any of the Publication Titles will open the Publication in a new internet browsing tab.

Collection Owners, Program Officers, and users with Submission or Administrative Privileges for the Collection may mark a publication as either Relevant or Not Relevant in the Status column.

Frequently Asked Questions

How can I determine if a publication is relevant?

Publications are considered relevant to a collection when the data shared is directly related to the project or collection.
Where does the NDA get the publications?

PubMed, an online library containing journals, articles, and medical research. Sponsored by NiH and National Library of Medicine (NLM).

Glossary

Create Study

A link to the Create an NDA Study page that can be clicked to start creating an NDA Study with information such as the title, journal and authors automatically populated.
Not Determined Publication

Indicates that the publication has not yet been reviewed and/or marked as Relevant or Not Relevant so it has not been determined whether an NDA Study is expected.
Not Relevant Publication

A publication that is not based on data related to the aims of the grant/project associated with the Collection or not based on any data such as a review article and, therefore, an NDA Study is not expected to be created.
PubMed

PubMed provides citation information for biomedical and life sciences publications and is managed by the U.S. National Institutes of Health's National Library of Medicine.
PubMed ID

The PUBMed ID is the unique ID number for the publication as recorded in the PubMed database.
Relevant Publication

A publication that is based on data related to the aims of the grant/project associated with the Collection and, therefore, an NDA Study is expected to be created.

Contact NDA Help Desk

Data Expected List: Mandatory Data Structures

These data structures are mandatory for your NDA Collection. Please update the Targeted Enrollment number to accurately represent the number of subjects you expect to submit for the entire study.

For NIMH HIV-related research that involves human research participants: Select the dictionary or dictionaries most appropriate for your research. If your research does not require all three data dictionaries, just ignore the ones you do not need. There is no need to delete extra data dictionaries from your NDA Collection. You can adjust the Targeted Enrollment column in the Data Expected tab to “0” for those unnecessary data dictionaries. At least one of the three data dictionaries must have a non-zero value.

Data Expected	Targeted Enrollment	Initial Submission	Subjects Submitted	Initial Share	Subjects Shared	Status
Genomics/omics	99	01/15/2015	0	05/15/2015	0	Approved
Research Subject and Pedigree	11	05/13/2015	673	05/13/2015	654	Approved

To create your project's Data Expected list, use the "+New Data Expected" to add or request existing structures and to request new Data Structures that are not in the NDA Data Dictionary.

If the Structure you need already exists, locate it and specify your dates and enrollment when adding it to your Data Expected list. If you require changes to the Structure you need, select the indicator stating "No, it requires changes to meet research needs," and upload a file containing your requested changes.

If the structure you need is not yet defined in the Data Dictionary, you can select "Upload Definition" and attach the necessary materials to request its creation.

When selecting the expected dates for your data, make sure to follow the standard Data Sharing Regimen and choose dates within the date ranges that correspond to your project start and end dates.

Please visit the Completing Your Data Expected Tutorial for more information.

Data Expected List: Data Structures per Research Aims

These data structures are specific to your research aims and should list all data structures in which data will be collected and submitted for this NDA Collection. Please update the Targeted Enrollment number to accurately represent the number of subjects you expect to submit for the entire study.

Data Expected	Targeted Enrollment	Initial Submission	Subjects Submitted	Initial Share	Subjects Shared	Status
Mullen Scales of Early Learning	11	05/13/2015	673	05/13/2015	654	Approved
ABC Community	99	01/15/2015	674	05/15/2015	655	Approved
ADOS	99	01/15/2015	393	05/15/2015	375	Approved
ADI-R	336	07/15/2014	469	11/15/2014	444	Approved
Early Development Questionnaire	382	01/15/2015	625	05/15/2015	608	Approved
Medical History	700	07/15/2014	676	11/15/2014	660	Approved
Genetic Test	99	01/15/2015	0	05/15/2015	0	Approved
Social Communication Questionnaire (SCQ)	99	01/15/2015	285	05/15/2015	279	Approved
Demographics	700	01/15/2016	674	05/15/2016	655	Approved
Enviromental Evaluation	99	01/15/2015	658	05/15/2015	639	Approved
Sleep History	99	07/15/2015	676	11/15/2015	658	Approved
Physical Exam	99	01/15/2015	424	07/31/2018	408	Approved
Vineland (Parent and Caregiver)	700	07/15/2014	733	11/15/2014	705	Approved
Product Questionnaire	99	01/15/2015	0	05/15/2015	0	Requested New

Structure not yet defined

No Status history for this Data Expected has been recorded yet

helpcenter.collection.data-expected-tab

Collection - Data Expected

The Data Expected tab displays the list of all data that NDA expects to receive in association with the Collection as defined by the contributing researcher, as well as the dates for the expected initial upload of the data, and when it is first expected to be shared, or with the research community. Above the primary table of Data Expected, any publications determined to be relevant to the data within the Collection are also displayed - members of the contributing research group can use these to define NDA Studies, connecting those papers to underlying data in NDA.

The tab is used both as a reference for those accessing shared data, providing information on what is expected and when it will be shared, and as the primary tracking mechanism for contributing projects. It is used by both contributing primary researchers, secondary researchers, and NIH Program and Grants Management staff.

Researchers who are starting their project need to update their Data Expected list to include all the Data Structures they are collecting under their grant and set their initial submission and sharing schedule according to the NDA Data Sharing Regimen.

To add existing Data Structures from the Data Dictionary, to request new Data Structure that are not in the Dictionary, or to request changes to existing Data Structures, click "+New Data Expected".

For step-by-step instructions on how to add existing Data Structures, request changes to an existing Structure, or request a new Data Structure, please visit the Completing Your Data Expected Tutorial.

If you are a contributing researcher creating this list for the first time, or making changes to the list as your project progress, please note the following:

Although items you add to the list and changes you make are displayed, they are not committed to the system until you Save the entire page using the "Save" button at the bottom of your screen. Please Save after every change to ensure none of your work is lost.
If you attempt to add a new structure, the title you provide must be unique - if another structure exists with the same name your change will fail.
Adding a new structure to this list is the only way to request the creation of a new Data Dictionary definition.

Frequently Asked Questions

What is an NDA Data Structure?

An NDA Data Structure is comprised of multiple Data Elements to make up an electronic definition of an assessment, measure, questionnaire, etc will have a corresponding Data Structure.
What is the NDA Data Dictionary?

The NDA Data Dictionary is comprised of electronic definitions known as Data Structures.

Glossary

Analyzed Data

Data specific to the primary aims of the research being conducted (e.g. outcome measures, other dependent variables, observations, laboratory results, analyzed images, volumetric data, etc.) including processed images.
Data Item

Items listed on the Data Expected list in the Collection which may be an individual and discrete Data Structure, Data Structure Category, or Data Structure Group.
Data Structure

A defined organization and group of Data Elements to represent an electronic definition of a measure, assessment, questionnaire, or collection of data points. Data structures that have been defined in the NDA Data Dictionary are available at https://nda.nih.gov/general-query.html?q=query=data-structure
Data Structure Category

An NDA term describing the affiliation of a Data Structure to a Category, which may be disease/disorder or diagnosis related (Depression, ADHD, Psychosis), specific to data type (MRI, eye tracking, omics), or type of data (physical exam, IQ).
Data Structure Group

A Data Item listed on the Data Expected tab of a Collection that indicates a group of Data Structures (e.g., ADOS or SCID) for which data may be submitted instead of a specific Data Structure identified by version, module, edition, etc. For example, the ADOS Data Structure Category includes every ADOS Data Structure such as ADOS Module 1, ADOS Module 2, ADOS Module 1 - 2nd Edition, etc. The SCID Data Structure Group includes every SCID Data Structure such as SCID Mania, SCID V Mania, SCID PTSD, SCID-V Diagnosis, and more.
Evaluated Data

A new Data Structure category, Evaluated Data is analyzed data resulting from the use of computational pipelines in the Cloud and can be uploaded directly back to a miNDAR database. Evaluated Data is expected to be listed as a Data Item in the Collection's Data Expected Tab.
Imaging Data

Imaging+ is an NDA term which encompasses all imaging related data including, but not limited to, images (DTI, MRI, PET, Structural, Spectroscopy, etc.) as well as neurosignal data (EEG, fMRI, MEG, EGG, eye tracking, etc.) and Evaluated Data.
Initial Share Date

Initial Submission and Initial Share dates should be populated according to the NDA Data Sharing Terms and Conditions. Any modifications to these will go through the approval processes outlined above. Data will be shared with authorized users upon publication (via an NDA Study) or 1-2 years after the grant end date specified on the first Notice of Award, as defined in the applicable Data Sharing Terms and Conditions.
Initial Submission Date

Initial Submission and Initial Share dates should be populated according to these NDA Data Sharing Terms and Conditions. Any modifications to these will go through the approval processes outlined above. Data for all subjects is not expected on the Initial Submission Date and modifications may be made as necessary based on the project's conduct.
Research Subject and Pedigree

An NDA created Data Structure used to convey basic information about the subject such as demographics, pedigree (links family GUIDs), diagnosis/phenotype, and sample location that are critical to allow for easier querying of shared data.
Submission Cycle

The NDA has two Submission Cycles per year - January 15 and July 15.
Submission Exemption

An interface to notify NDA that data may not be submitted during the upcoming/current submission cycle.

Contact NDA Help Desk

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Associated Studies

Studies that have been defined using data from a Collection are important criteria to determine the value of data shared. The number of subjects column displays the counts from this Collection that are included in a Study, out of the total number of subjects in that study. The Data Use column represents whether or not the study is a primary analysis of the data or a secondary analysis. State indicates whether the study is private or shared with the research community.

Study NameFilter by Study Name	DOIFilter by DOI	AbstractFilter by Abstract	Collection/Study SubjectsFilter by Collection/Study Subjects	Data UsageFilter by Data Usage	StateFilter by State
Examining the validity of the use of ratio IQs in psychological assessments	10.15154/1522624	IQ tests are amongst the most used psychological assessments, both in research and clinical settings. For participants who cannot complete IQ tests normed for their age, ratio IQ scores (RIQ) are routinely computed and used as a proxy of IQ, especially in large research databases to avoid missing data points. However, because it has never been scientifically validated, this practice is questionable. In the era of big data, it is important to examine the validity of this widely used practice. In this paper, we use the case of autism to examine the differences between standard full-scale IQ (FSIQ) and RIQ. Data was extracted from four databases in which ages, FSIQ scores and subtests raw scores were available for autistic participants between 2 and 17 years old. The IQ tests included were the MSEL (N=12033), DAS-II early years (N=1270), DAS-II school age (N=2848), WISC-IV (N=471) and WISC-V (N=129). RIQs were computed for each participant as well as the discrepancy (DSC) between RIQ and FSIQ. We performed two linear regressions to respectively assess the effect of FSIQ and of age on the DSC for each IQ test, followed by additional analyses comparing age subgroups as well as FSIQ subgroups on DSC. Participants at the extremes of the FSIQ distribution tended to have a greater DSC than participants with average FSIQ. Furthermore, age significantly predicted the DSC, with RIQ superior to FSIQ for younger participants while the opposite was found for older participants. These results question the validity of this widely used alternative scoring method, especially for individuals at the extremes of the normal distribution, with whom RIQs are most often employed.	476/17423	Secondary Analysis	Shared
The importance of low IQ to early diagnosis of autism	10.15154/1528140	Some individuals can flexibly adapt to life’s changing demands while others, in particular those with Autism Spectrum Disorder (ASD), find it challenging. The origin of early individual differences in cognitive abilities, the putative tools with which to navigate novel information in life, including in infants later diagnosed with ASD remains unexplored. Moreover, the role of intelligence quotient (IQ) vis-à-vis core features of autism remains debated. We systematically investigate the contribution of early IQ in future autism outcomes in an extremely large, population-based study of 8,000 newborns, infants, and toddlers from the US between 2 and 68 months with over 15,000 cross-sectional and longitudinal assessments, and for whom autism outcomes are ascertained or ruled out by about 2-4 years. This population is representative of subjects involved in the National Institutes of Health (NIH)-funded research, mainly on atypical development, in the US. Analyses using predetermined age bins showed that IQ scores are consistently lower in ASD relative to TD at all ages (p<0.001), and IQ significantly correlates with calibrated severity scores (total CSS, as well as non-verbal and verbal CSS) on the ADOS. Note, VIQ is no better than the full-scale IQ to predict ASD cases. These findings raise new, compelling questions about potential atypical brain circuitry affecting performance in both verbal and nonverbal abilities and that precede an ASD diagnosis. This study is the first to establish prospectively that low early IQ is a major feature of ASD in early childhood.	460/6323	Secondary Analysis	Shared
Prognostic early snapshot stratification of autism based on adaptive functioning	10.15154/0z1c-1d37	A major goal of precision medicine is to predict prognosis based on individualized information at the earliest possible points in development. Using early snapshots of adaptive functioning and unsupervised data- driven discovery methods, we uncover highly stable early autism subtypes that yield information relevant to later prognosis. Data from the National Institute of Mental Health Data Archive (NDA) (n = 1,098) was used to uncover three early subtypes (<72 months) that generalize with 96% accuracy. Outcome data from NDA (n = 2,561; mean age, 13 years) also reproducibly clusters into three subtypes with 99% generalization accuracy. Early snapshot subtypes predict developmental trajectories in non-verbal cognitive, language and motor domains and are predictive of membership in different adaptive functioning outcome subtypes. Robust and prognosis- relevant subtyping of autism based on early snapshots of adaptive functioning may aid future research work via prediction of these subtypes with our reproducible stratification model.	22/3517	Secondary Analysis	Shared
Investigating autism etiology and heterogeneity by decision tree algorithm	10.15154/1518655	Autism spectrum disorder (ASD) is a neurodevelopmental disorder that causes deficits in cognition, communication and social skills. ASD, however, is a highly heterogeneous disorder. This heterogeneity has made identifying the etiology of ASD a particularly difficult challenge, as patients exhibit a wide spectrum of symptoms without any unifying genetic or environmental factors to account for the disorder. For better understanding of ASD, it is paramount to identify potential genetic and environmental risk factors that are comorbid with it. Identifying such factors is of great importance to determine potential causes for the disorder, and understand its heterogeneity. Existing large-scale datasets offer an opportunity for computer scientists to undertake this task by utilizing machine learning to reliably and efficiently obtain insight about potential ASD risk factors, which would in turn assist in guiding research in the field. In this study, decision tree algorithms were utilized to analyze related factors in datasets obtained from the National Database for Autism Research (NDAR) consisting of nearly 3000 individuals. We were able to identify 15 medical conditions that were highly associated with ASD diagnoses in patients; furthermore, we extended our analysis to the family medical history of patients and we report six potentially hereditary medical conditions associated with ASD. Associations reported had a 90% accuracy. Meanwhile, gender comparisons highlighted conditions that were unique to each gender and others that overlapped. Those findings were validated by the academic literature, thus opening the way for new directions for the use of decision tree algorithms to further understand the etiology of autism.	96/3382	Secondary Analysis	Shared
Imbalanced social-communicative and restricted repetitive behavior subtypes in autism spectrum disorder exhibit different neural circuitry	10.15154/1524418	Social-communication (SC) and restricted repetitive behaviors (RRB) are autism diagnostic symptom domains. SC and RRB severity can markedly differ within and between individuals and may be underpinned by different neural circuitry and genetic mechanisms. Modeling SC-RRB balance could help identify how neural circuitry and genetic mechanisms map onto such phenotypic heterogeneity. Here, we developed a phenotypic stratification model that makes highly accurate (97–99%) out-of-sample SC = RRB, SC > RRB, and RRB > SC subtype predictions. Applying this model to resting state fMRI data from the EU-AIMS LEAP dataset (n = 509), we find that while the phenotypic subtypes share many commonalities in terms of intrinsic functional connectivity, they also show replicable differences within some networks compared to a typically-developing group (TD). Specifically, the somatomotor network is hypoconnected with perisylvian circuitry in SC > RRB and visual association circuitry in SC = RRB. The SC = RRB subtype show hyperconnectivity between medial motor and anterior salience circuitry. Genes that are highly expressed within these networks show a differential enrichment pattern with known autism-associated genes, indicating that such circuits are affected by differing autism-associated genomic mechanisms. These results suggest that SC-RRB imbalance subtypes share many commonalities, but also express subtle differences in functional neural circuitry and the genomic underpinnings behind such circuitry.	120/1708	Secondary Analysis	Shared
Sensorimotor variability distinguishes early features of cognition in toddlers with autism	10.15154/qfej-cf04	The potential role of early sensorimotor features to atypical human cognition in autistic children has received surprisingly little attention given that appropriate movements are a crucial element that connects us to other people. Crucially it is sensorimotor function prior to the development of autism which would be of most interest in terms of establishing causal links. We examined movements acquired during natural sleep in over 200 toddlers recruited for neuroimaging studies, months before they were diagnosed with Autism Spectrum Disorder (ASD) or were ascertained as typically developing. We show there are significant correlations between objective, quantitative features of the distribution of head speed in the scanner (coefficient of variance and skewness) and subsequent cognitive abilities (intelligence quotient, IQ) in these children. Relative to higher-IQ ASD toddlers, those with lower-IQ had significantly altered sensorimotor features. Remarkably, we found that higher cognitive abilities in autistic toddlers confer resilience to atypical movement, as sensorimotor features in higher-IQ ASD toddlers were indistinguishable from those of typically developing healthy control toddlers. In a second set of analyses, we examined general motor skills assessed using observational instruments during wakefulness in an independent sample of over 1,000 infants and toddlers who received ASD diagnoses by 3-4 years. We detected significantly lower motor scores for lower-IQ vs. higher IQ autistic children, at 6, 12, 18, 24, and 30 months. We suggest that the altered movement patterns may affect key autistic behaviors in those with lower intelligence by affecting sensorimotor learning mechanisms. Atypical sensorimotor functioning is a novel, key feature in lower-IQ early childhood autism.	5/1078	Secondary Analysis	Shared

* Data not on individual level

helpcenter.collection.associated-studies-tab

Collection - Associated Studies

Clicking on the Study Title will open the study details in a new internet browser tab. The Abstract is available for viewing, providing the background explanation of the study, as provided by the Collection Owner.

Primary v. Secondary Analysis: The Data Usage column will have one of these two choices. An associated study that is listed as being used for Primary Analysis indicates at least some and potentially all of the data used was originally collected by the creator of the NDA Study. Secondary Analysis indicates the Study owner was not involved in the collection of data, and may be used as supporting data.

Private v. Shared State: Studies that remain private indicate the associated study is only available to users who are able to access the collection. A shared study is accessible to the general public.

Frequently Asked Questions

How do I associate a study to my collection?

Studies are associated to the Collection automatically when the data is defined in the Study.

Glossary

Associated Studies Tab

A tab in a Collection that lists the NDA Studies that have been created using data from that Collection including both Primary and Secondary Analysis NDA Studies.

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