NIMH Data Archive - Data

Genomics

Neuroimaging

Phenotype¹

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Clinical Trial

¹ Numbers reported are subjects by age

New Project
Grant/Project Number

Format should be in the following format: Activity Code, Institute Abbreviation, and Serial Number. Grant Type, Support Year, and Suffix should be excluded. For example, grant 1R01MH123456-01A1 should be entered R01MH123456

Collection - Use Existing Experiment

To associate an experiment to the current collection, just select an axperiment from the table below then click the associate experiment button to persist your changes (saving the collection is not required). Note that once an experiment has been associated to two or more collections, the experiment will not longer be editable.

The table search feature is case insensitive and targets the experiment id, experiment name and experiment type columns. The experiment id is searched only when the search term entered is a number, and filtered using a startsWith comparison. When the search term is not numeric the experiment name is used to filter the results.

Select	Experiment Id	Experiment Name	Experiment Type	Created On

24	HI-NGS_R1	Omics	02/16/2011
475	MB1-10 (CHOP)	Omics	06/07/2016
490	Discovery and CRISPR validation of genetic factors associated with antipsychotic-induced weight gain and cardiometabolic risk	Omics	07/07/2016
501	PharmacoBOLD Resting State	fMRI	07/27/2016
506	PVPREF	Omics	08/05/2016
509	ABC-CT Resting v2	EEG	08/18/2016
13	Comparison of FI expression in Autistic and Neurotypical Homo Sapiens	Omics	12/28/2010
18	AGRE/Broad Affymetrix 5.0 Genotype Experiment	Omics	01/06/2011
22	Stitching PCR Sequencing	Omics	02/14/2011
26	ASD_Methylation	Omics	03/01/2011
29	Microarray family 03 (father, mother, sibling)	Omics	03/24/2011
37	Standard paired-end sequencing of BCRs	Omics	04/19/2011
38	Illumina Mate-Pair BCR sequencing	Omics	04/19/2011
39	Custom Jumping Libraries	Omics	04/19/2011
40	Custom CapBP	Omics	04/19/2011
41	Immunofluorescence	Omics	05/11/2011
43	Autism brain sample genotyping, Illumina	Omics	05/16/2011
47	ARRA Autism Sequencing Collaboration at Baylor. SOLiD 4 System	Omics	08/01/2011
53	AGRE Omni1-quad	Omics	10/11/2011
59	AGP genotyping	Omics	04/03/2012
60	Ultradeep 454 sequencing of synaptic genes from postmortem cerebella of individuals with ASD and neurotypical controls	Omics	06/23/2012
63	Microemulsion PCR and Targeted Resequencing for Variant Detection in ASD	Omics	07/20/2012
76	Whole Genome Sequencing in Autism Families	Omics	01/03/2013
519	Resting	fMRI	11/08/2016
90	Genotyped IAN Samples	Omics	07/09/2013
91	NJLAGS Axiom Genotyping Array	Omics	07/16/2013
93	AGP genotyping (CNV)	Omics	09/06/2013
106	Longitudinal Sleep Study. H20 200. Channel set 2	EEG	11/07/2013
107	Longitudinal Sleep Study. H20 200. Channel set 3	EEG	11/07/2013
108	Longitudinal Sleep Study. AURA 200	EEG	11/07/2013
105	Longitudinal Sleep Study. H20 200. Channel set 1	EEG	11/07/2013
109	Longitudinal Sleep Study. AURA 400	EEG	11/07/2013
116	Gene Expression Analysis WG-6	Omics	01/07/2014
131	Jeste Lab UCLA ACEii: Charlie Brown and Sesame Street - Project 1	Eye Tracking	02/27/2014
132	Jeste Lab UCLA ACEii: Animacy - Project 1	Eye Tracking	02/27/2014
133	Jeste Lab UCLA ACEii: Mom Stranger - Project 2	Eye Tracking	02/27/2014
134	Jeste Lab UCLA ACEii: Face Emotion - Project 3	Eye Tracking	02/27/2014
145	AGRE/FMR1_Illumina.JHU	Omics	04/14/2014
146	AGRE/MECP2_Sanger.JHU	Omics	04/14/2014
147	AGRE/MECP2_Junior.JHU	Omics	04/14/2014
151	Candidate Gene Identification in familial Autism	Omics	06/09/2014
152	NJLAGS Whole Genome Sequencing	Omics	07/01/2014
154	Math Autism Study - Vinod Menon	fMRI	07/15/2014
155	Resting	fMRI	07/25/2014
156	Speech	fMRI	07/25/2014
159	Emotion	fMRI	07/25/2014
160	syllable contrast	EEG	07/29/2014
167	School-age naturalistic stimuli	Eye Tracking	09/19/2014
44	AGRE/Broad Affymetrix 5.0 Genotype Experiment	Omics	06/27/2011
45	Exome Sequencing of 20 Sporadic Cases of Autism Spectrum Disorder	Omics	07/15/2011

Collection - Add Experiment

Add Supporting Documentation

Funding Source:
URL:

To add an existing Data Structure, enter its title in the search bar. If you need to request changes, select the indicator "No, it requires changes to meet research needs" after selecting the Structure, and upload the file with the request changes specific to the selected Data Structure. Your file should follow the Request Changes Procedure. If the Data Structure does not exist, select "Request New Data Structure" and upload the appropriate zip file.

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The Data Expected list for this Collection shows some raw data as missing. Contact the NDA Help Desk with any questions.

Please confirm that you will not be enrolling any more subjects and that all raw data has been collected and submitted.

Collection Updated

Your Collection is now in Data Analysis phase and exempt from biannual submissions. Analyzed data is still expected prior to publication or no later than the project end date.

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[CMS]

Unable to change collection phase where targeted enrollment is less than 90%

You have requested to move the sharing dates for the following assessments:

Data Expected Item	Original Sharing Date	New Sharing Date

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Atypical Late Neurodevelopment in Autism #1906

General
Experiments (0)
Shared Data
Publications (90)
Data Expected (36)
Associated Studies (9)

Collection Title	Collection Investigators	Collection Description
Collection Title:	Atypical Late Neurodevelopment in Autism
Collection Investigators:	Janet E Lainhart, MD
Collection Description:	Longitudinal neuroimaging and neuropsychological study to understand how brain mechanisms and clinical phenotypes in autism are related.
Data Repository:	NIMH Data Archive
Permission Group:
Collection Creation Date:	02/13/2012
Collection Phase:	Funding Completed
Collection Sub-Phase:	Close Out
Blinded Clinical Trial:	No
Total Funded Amount:	$3,795,841.00
Subjects Shared:	174
Collection DOI:	10.15154/bx96-q537

{"values":[]}

{"values":[["DTI",131],["MRI",131]]}

{"values":[["Autism Spectrum Severely Affected",29],["Neurological Control",7],["Not Defined",260],["Autism Spectrum Affected",1]]}

Loading Chart...

Funding Sources:

Funding Source Name	Funding Source URL
NIH - Extramural	None

Supporting Documentation:

File Name	File Type	Description	Audience
QA-notification.txt	Other	Quality Assurance Notification	Qualified Researchers

Grant Information:

Project Number	Title	Start Date	Original End Date	End Date	Planned Enrollment	Actual Enrollment	Organization	Funds Obligated
R01MH080826-01	Atypical Late Neurodevelopment in Autism: A Longitudinal MRI and DTI Study	08/01/2007	07/31/2012	07/31/2012	172	172	UNIVERSITY OF UTAH	$2,218,307.00
R01MH084795-01	The Microstructural Basis of Abnormal Connectivity in Autism	04/01/2009	01/31/2014	01/31/2014	Not Reported	Not Reported	UNIVERSITY OF UTAH	$1,577,534.00

Clinical Trials:

helpcenter.collection.general-tab

Collection - General Tab

Fields available for edit on the top portion of the page include:

Collection Title
Investigators
Collection Description
Collection Phase
Funding Source
Clinical Trials

Collection Phase: The current status of a research project submitting data to an NDA Collection, based on the timing of the award and/or the data that have been submitted.

Pre-Enrollment: The default entry made when the NDA Collection is created.
Enrolling: Data have been submitted to the NDA Collection or the NDA Data Expected initial submission date has been reached for at least one data structure category in the NDA Collection.
Data Analysis: Subject level data collection for the research project is completed and has been submitted to the NDA Collection. The NDA Collection owner or the NDA Help Desk may set this phase when they’ve confirmed data submission is complete and submitted subject counts match at least 90% of the target enrollment numbers in the NDA Data Expected. Data submission reminders will be turned off for the NDA Collection.
Funding Completed: The NIH grant award (or awards) associated with the NDA Collection has reached its end date. NDA Collections in Funding Completed phase are assigned a subphase to indicate the status of data submission.
- The Data Expected Subphase indicates that NDA expects more data will be submitted
- The Closeout Subphase indicates the data submission is complete.
- The Sharing Not Met Subphase indicates that data submission was not completed as expected.

Blinded Clinical Trial Status:

This status is set by a Collection Owner and indicates the research project is a double blinded clinical trial. When selected, the public view of Data Expected will show the Data Expected items and the Submission Dates, but the targeted enrollment and subjects submitted counts will not be displayed.
Targeted enrollment and subjects submitted counts are visible only to NDA Administrators and to the NDA Collection or as the NDA Collection Owner.
When an NDA Collection that is flagged Blinded Clinical Trial reaches the maximum data sharing date for that Data Repository (see https://nda.nih.gov/nda/sharing-regimen.html), the embargo on Data Expected information is released.

Funding Source

The organization(s) responsible for providing the funding is listed here.

Supporting Documentation

Users with Submission privileges, as well as Collection Owners, Program Officers, and those with Administrator privileges, may upload and attach supporting documentation. By default, supporting documentation is shared to the general public, however, the option is also available to limit this information to qualified researchers only.

Grant Information

Identifiable details are displayed about the Project of which the Collection was derived from. You may click in the Project Number to view a full report of the Project captured by the NIH.

Clinical Trials

Any data that is collected to support or further the research of clinical studies will be available here. Collection Owners and those with Administrator privileges may add new clinical trials.

Frequently Asked Questions

How does the NIMH Data Archive (NDA) determine which Permission Group data are submitted into?

During Collection creation, NDA staff determine the appropriate Permission Group based on the type of data to be submitted, the type of access that will be available to data access users, and the information provided by the Program Officer during grant award.
How do I know when a NDA Collection has been created?

When a Collection is created by NDA staff, an email notification will automatically be sent to the PI(s) of the grant(s) associated with the Collection to notify them.
Is a single grant number ever associated with more than one Collection?

The NDA system does not allow for a single grant to be associated with more than one Collection; therefore, a single grant will not be listed in the Grant Information section of a Collection for more than one Collection.
Why is there sometimes more than one grant included in a Collection?

In general, each Collection is associated with only one grant; however, multiple grants may be associated if the grant has multiple competing segments for the same grant number or if multiple different grants are all working on the same project and it makes sense to hold the data in one Collection (e.g., Cooperative Agreements).

Glossary

Administrator Privilege

A privilege provided to a user associated with an NDA Collection or NDA Study whereby that user can perform a full range of actions including providing privileges to other users.
Collection Owner

Generally, the Collection Owner is the contact PI listed on a grant. Only one NDA user is listed as the Collection owner. Most automated emails are primarily sent to the Collection Owner.
Collection Phase
The Collection Phase provides information on data submission as opposed to grant/project completion so while the Collection phase and grant/project phase may be closely related they are often different. Collection users with Administrative Privileges are encouraged to edit the Collection Phase. The Program Officer as listed in eRA (for NIH funded grants) may also edit this field. Changes must be saved by clicking the Save button at the bottom of the page. This field is sortable alphabetically in ascending or descending order. Collection Phase options include:
- Pre-Enrollment: A grant/project has started, but has not yet enrolled subjects.
- Enrolling: A grant/project has begun enrolling subjects. Data submission is likely ongoing at this point.
- Data Analysis: A grant/project has completed enrolling subjects and has completed all data submissions.
- Funding Completed: A grant/project has reached the project end date.
Collection Title

An editable field with the title of the Collection, which is often the title of the grant associated with the Collection.
Grant

Provides the grant number(s) for the grant(s) associated with the Collection. The field is a hyperlink so clicking on the Grant number will direct the user to the grant information in the NIH Research Portfolio Online Reporting Tools (RePORT) page.
Supporting Documentation

Various documents and materials to enable efficient use of the data by investigators unfamiliar with the project and may include the research protocol, questionnaires, and study manuals.
NIH Research Initiative

NDA Collections may be organized by scientific similarity into NIH Research Initiatives, to facilitate query tool user experience. NIH Research Initiatives map to one or multiple Funding Opportunity Announcements.
Permission Group

Access to shared record-level data in NDA is provisioned at the level of a Permission Group. NDA Permission Groups consist of one or multiple NDA Collections that contain data with the same subject consents.
Planned Enrollment

Number of human subject participants to be enrolled in an NIH-funded clinical research study. The data is provided in competing applications and annual progress reports.
Actual Enrollment

Number of human subjects enrolled in an NIH-funded clinical research study. The data is provided in annual progress reports.
NDA Collection

A virtual container and organization structure for data and associated documentation from one grant or one large project/consortium. It contains tools for tracking data submission and allows investigators to define a wide array of other elements that provide context for the data, including all general information regarding the data and source project, experimental parameters used to collect any event-based data contained in the Collection, methods, and other supporting documentation. They also allow investigators to link underlying data to an NDA Study, defining populations and subpopulations specific to research aims.
Data Use Limitations

Data Use Limitations (DULs) describe the appropriate secondary use of a dataset and are based on the original informed consent of a research participant. NDA only accepts consent-based data use limitations defined by the NIH Office of Science Policy.
Total Subjects Shared

The total number of unique subjects for whom data have been shared and are available for users with permission to access data.

Contact NDA Help Desk

ID	Name	Created Date	Status	Type
No records found.

helpcenter.collection.experiments-tab

Collection - Experiments

The number of Experiments included is displayed in parentheses next to the tab name. You may download all experiments associated with the Collection via the Download button. You may view individual experiments by clicking the Experiment Name and add them to the Filter Cart via the Add to Cart button.

Collection Owners, Program Officers, and users with Submission or Administrative Privileges for the Collection may create or edit an Experiment.

Please note: The creation of an NDA Experiment does not necessarily mean that data collected, according to the defined Experiment, has been submitted or shared.

Frequently Asked Questions

Can an Experiment be associated with more than one Collection?
Yes -see the “Copy” button in the bottom left when viewing an experiment. There are two actions that can be performed via this button:
1. Copy the experiment with intent for modifications.
2. Associate the experiment to the collection. No modifications can be made to the experiment.

Glossary

Experiment Status

An Experiment must be Approved before data using the associated Experiment_ID may be uploaded.
Experiment ID

The ID number automatically generated by NDA which must be included in the appropriate file when uploading data to link the Experiment Definition to the subject record.

Contact NDA Help Desk

Shared Data:

Title	Type	Number of Subjects
Aberrant Behavior Checklist (ABC) - Community	Clinical Assessments	129
Anthropometric Information	Clinical Assessments	158
Autism Diagnostic Interview - Cumulative	Clinical Assessments	90
Autism Diagnostic Observation Schedule (ADOS) - Module 4	Clinical Assessments	60
Autism Diagnostic Observation Schedule (ADOS)- Module 1	Clinical Assessments	11
Autism Diagnostic Observation Schedule (ADOS)- Module 2	Clinical Assessments	18
Autism Diagnostic Observation Schedule (ADOS)- Module 3	Clinical Assessments	58
Autism Spectrum Quotient (AQ)	Clinical Assessments	59
Beck Depression Inventory	Clinical Assessments	91
CADS-P	Clinical Assessments	150
CELF Preschool	Clinical Assessments	21
CELF-3 Clinical Eval of Lang Fundamentals, 3th ed	Clinical Assessments	152
CELF-4 Clinical Eval of Lang Fundamentals, 4th ed	Clinical Assessments	29
Children's Communication Checklist - 2	Clinical Assessments	10
Communication Checklist - Adult	Clinical Assessments	22
Comprehensive Test of Phonological Processing (CTOPP)	Clinical Assessments	159
DAS-II: Differential Ability Scales 2nd Ed. School Age	Clinical Assessments	65
DAS-II:Differential Ability Scales 2nd Ed. Early Years	Clinical Assessments	19
Developmental Behavior Checklist	Clinical Assessments	141
Edinburgh Handedness Inventory	Clinical Assessments	121
Empathy Quotient	Clinical Assessments	54
Expressive Vocabulary Test	Clinical Assessments	144
Finger Tapping Test	Clinical Assessments	106
Grooved Pegboard Test	Clinical Assessments	133
Halstead-Reitan Grip Strength	Clinical Assessments	156
Hooper Visual Organization Test (VOT)	Clinical Assessments	137
Image	Imaging	165
Mullen Scales of Early Learning	Clinical Assessments	3
Peabody Picture Vocabulary Test, Third Edition (Form A)	Clinical Assessments	146
Pubertal Development Scale	Clinical Assessments	148
Research Subject	Clinical Assessments	170
Screen for Child Anxiety Related Disorders (SCARED), Parent/Child	Clinical Assessments	135
Sensory Profile Caregiver	Clinical Assessments	117
Social Responsiveness Scale (SRS)	Clinical Assessments	108
Social Responsiveness Scale (SRS) - Adult/Self Version	Clinical Assessments	91
Systemising Quotient	Clinical Assessments	43
Test of Memory and Learning (TOMAL)	Clinical Assessments	110
Toronto Alexithymia Scale	Clinical Assessments	78
Trail Making Test, Child and Adult	Clinical Assessments	146
Vineland I	Clinical Assessments	116
Wechsler Abbreviated Scale of Intelligence (WASI)	Clinical Assessments	126
Wechsler Adult Intelligence Scale Fourth Edition [part 1]	Clinical Assessments	32
Wechsler Adult Intelligence Scale III	Clinical Assessments	114
Wechsler Intelligence Scale for Children III	Clinical Assessments	69
Wide Range Achievement Test 3 (WRAT3)	Clinical Assessments	77

helpcenter.collection.shared-data-tab

Collection - Shared Data

This tab provides a quick overview of the Data Structure title, Data Type, and Number of Subjects that are currently Shared for the Collection. The information presented in this tab is automatically generated by NDA and cannot be edited. If no information is visible on this tab, this would indicate the Collection does not have shared data or the data is private.

The shared data is available to other researchers who have permission to access data in the Collection's designated Permission Group(s). Use the Download button to get all shared data from the Collection to the Filter Cart.

Frequently Asked Questions

How will I know if another researcher uses data that I shared through the NIMH Data Archive (NDA)?

To see what data your project have submitted are being used by a study, simply go the Associated Studies tab of your collection. Alternatively, you may review an NDA Study Attribution Report available on the General tab.
Can I get a supplement to share data from a completed research project?

Often it becomes more difficult to organize and format data electronically after the project has been completed and the information needed to create a GUID may not be available; however, you may still contact a program staff member at the appropriate funding institution for more information.
Can I get a supplement to share data from a research project that is still ongoing?

Unlike completed projects where researchers may not have the information needed to create a GUID and/or where the effort needed to organize and format data becomes prohibitive, ongoing projects have more of an opportunity to overcome these challenges. Please contact a program staff member at the appropriate funding institution for more information.

Glossary

Data Structure

A defined organization and group of Data Elements to represent an electronic definition of a measure, assessment, questionnaire, or collection of data points. Data structures that have been defined in the NDA Data Dictionary are available at https://nda.nih.gov/general-query.html?q=query=data-structure
Data Type

A grouping of data by similar characteristics such as Clinical Assessments, Omics, or Neurosignal data.
Shared

The term 'Shared' generally means available to others; however, there are some slightly different meanings based on what is Shared. A Shared NDA Study is viewable and searchable publicly regardless of the user's role or whether the user has an NDA account. A Shared NDA Study does not necessarily mean that data used in the NDA Study have been shared as this is independently determined. Data are shared according the schedule defined in a Collection's Data Expected Tab and/or in accordance with data sharing expectations in the NDA Data Sharing Terms and Conditions. Additionally, Supporting Documentation uploaded to a Collection may be shared independent of whether data are shared.

Contact NDA Help Desk

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Publications

Publications relevant to NDA data are listed below. Most displayed publications have been associated with the grant within Pubmed. Use the "+ New Publication" button to add new publications. Publications relevant/not relevant to data expected are categorized. Relevant publications are then linked to the underlying data by selecting the Create Study link. Study provides the ability to define cohorts, assign subjects, define outcome measures and lists the study type, data analysis and results. Analyzed data and results are expected in this way.

PubMed ID	Study	Title	Journal	Authors	Date	Status
41425862	Create Study	Dr. Temple Grandin: Neuropsychological Assessment and a Multimodal Neuroimaging Case Study of a Distinguished Scientist, Educator, and Person With Autism.	Journal of pediatric neuropsychology	Bigler, Erin D; Grandin, Temple; Cooperrider, Jaice; Abildskov, Tracy J; Anderson, Jeffrey S; King, Jace B; Dean 3rd, Douglas; Guerrero-Gonzalez, Jose; Alexander, Andrew L; Prigge, Molly B D; Froehlich, Alyson; Zielinski, Brandon A; Lange, Nicholas; Taylor, June; Adluru, Nagesh; Lainhart, Janet E	September 1, 2025	Not Determined
38720286	Create Study	Reduced lateralization of multiple functional brain networks in autistic males.	Journal of neurodevelopmental disorders	Peterson, Madeline; Prigge, Molly B D; Floris, Dorothea L; Bigler, Erin D; Zielinski, Brandon A; King, Jace B; Lange, Nicholas; Alexander, Andrew L; Lainhart, Janet E; Nielsen, Jared A	May 8, 2024	Not Determined
38187671	Create Study	Reduced Lateralization of Multiple Functional Brain Networks in Autistic Males.	bioRxiv : the preprint server for biology	Peterson, Madeline; Prigge, Molly B D; Floris, Dorothea L; Bigler, Erin D; Zielinski, Brandon; King, Jace B; Lange, Nicholas; Alexander, Andrew L; Lainhart, Janet E; Nielsen, Jared A	December 18, 2023	Not Determined
37829720	Create Study	Tract- and gray matter- based spatial statistics show white matter and gray matter microstructural differences in autistic males.	Frontiers in neuroscience	DiPiero, Marissa; Cordash, Hassan; Prigge, Molly B; King, Carolyn K; Morgan, Jubel; Guerrero-Gonzalez, Jose; Adluru, Nagesh; King, Jace B; Lange, Nicholas; Bigler, Erin D; Zielinski, Brandon A; Alexander, Andrew L; Lainhart, Janet E; Dean 3rd, Douglas C	January 1, 2023	Not Determined
36587584	Create Study	Gray matter microstructure differences in autistic males: A gray matter based spatial statistics study.	NeuroImage. Clinical	DiPiero, Marissa A; Surgent, Olivia J; Travers, Brittany G; Alexander, Andrew L; Lainhart, Janet E; Dean Iii, Douglas C	January 1, 2023	Not Determined
36032692	Create Study	Test-retest reliability of FreeSurfer-derived volume, area and cortical thickness from MPRAGE and MP2RAGE brain MRI images.	Neuroimage. Reports	Knussmann, Graham N; Anderson, Jeffrey S; Prigge, Molly B D; Dean 3rd, Douglas C; Lange, Nicholas; Bigler, Erin D; Alexander, Andrew L; Lainhart, Janet E; Zielinski, Brandon A; King, Jace B	June 1, 2022	Not Determined
34677753	Create Study	Longitudinal Stability of Intellectual Functioning in Autism Spectrum Disorder: From Age 3 Through Mid-adulthood.	Journal of autism and developmental disorders	Prigge, Molly B D; Bigler, Erin D; Lange, Nicholas; Morgan, Jubel; Froehlich, Alyson; Freeman, Abigail; Kellett, Kristina; Kane, Karen L; King, Carolyn K; Taylor, June; Dean 3rd, Douglas C; King, Jace B; Anderson, Jeff S; Zielinski, Brandon A; Alexander, Andrew L; Lainhart, Janet E	October 1, 2022	Not Determined
34384526	Create Study	Sex Differences in Cerebral Development in Autism.	Biological psychiatry	Lainhart, Janet Elizabeth	September 1, 2021	Not Determined
34260891	Create Study	Evidence for normal extra-axial cerebrospinal fluid volume in autistic males from middle childhood to adulthood.	NeuroImage	Peterson, Madeline; Prigge, Molly B D; Bigler, Erin D; Zielinski, Brandon; King, Jace B; Lange, Nicholas; Alexander, Andrew; Lainhart, Janet E; Nielsen, Jared A	October 15, 2021	Not Determined
33878377	Create Study	A 16-year study of longitudinal volumetric brain development in males with autism.	NeuroImage	Prigge, Molly B D; Lange, Nicholas; Bigler, Erin D; King, Jace B; Dean 3rd, Douglas C; Adluru, Nagesh; Alexander, Andrew L; Lainhart, Janet E; Zielinski, Brandon A	August 1, 2021	Not Determined
32953403	Create Study	Beery VMI and Brain Volumetric Relations in Autism Spectrum Disorder.	Journal of pediatric neuropsychology	Green, Ryan R; Bigler, Erin D; Froehlich, Alyson; Prigge, Molly B D; Zielinski, Brandon A; Travers, Brittany G; Anderson, Jeffrey S; Alexander, Andrew; Lange, Nicholas; Lainhart, Janet E	September 1, 2019	Not Determined
31815759	Create Study	The development of the social brain in baby siblings of children with autism.	Current opinion in psychiatry	Dean 3rd, Douglas C; Freeman, Abigail; Lainhart, Janet	March 2020	Not Determined
31401546	Create Study	Functional connectivity of emotional well-being: Overconnectivity between default and attentional networks is associated with attitudes of anger and aggression.	Psychiatry research. Neuroimaging	Weathersby, Fiona L; King, Jace B; Fox, J Chancelor; Loret, Amy; Anderson, Jeffrey S	September 2019	Not Determined
31285817	Create Study	Generalizability and reproducibility of functional connectivity in autism.	Molecular autism	King JB, Prigge MBD, King CK, Morgan J, Weathersby F, Fox JC, Dean DC, Freeman A, Villaruz JAM, Kane KL, Bigler ED, Alexander AL, Lange N, Zielinski B, Lainhart JE, Anderson JS	January 2019	Not Determined
31152181	Create Study	Neural reward processing in self-reported short sleepers: examination of gambling task brain activation in the Human Connectome Project database.	Sleep	Curtis, Brian J; Williams, Paula G; Anderson, Jeffrey S	September 6, 2019	Not Determined
30864835	Create Study	Neuroimaging in Psychiatry and Neurodevelopment: why the emperor has no clothes.	The British journal of radiology	Anderson AN, King JB, Anderson JS	September 2019	Not Determined
30833582	Create Study	Atypical functional connectome hierarchy in autism.	Nature communications	Hong, Seok-Jun; Vos de Wael, Reinder; Bethlehem, Richard A I; Lariviere, Sara; Paquola, Casey; Valk, Sofie L; Milham, Michael P; Di Martino, Adriana; Margulies, Daniel S; Smallwood, Jonathan; Bernhardt, Boris C	March 2019	Not Determined
30646371	Create Study	Evaluation of Differences in Temporal Synchrony Between Brain Regions in Individuals With Autism and Typical Development.	JAMA network open	King, Jace B; Prigge, Molly B D; King, Carolyn K; Morgan, Jubel; Dean 3rd, Douglas C; Freeman, Abigail; Villaruz, Joaquin Alfonso M; Kane, Karen L; Bigler, Erin D; Alexander, Andrew L; Lange, Nicholas; Zielinski, Brandon A; Lainhart, Janet E; Anderson, Jeffrey S	November 2018	Not Determined
30603063	Create Study	Functional MRI connectivity of children with autism and low verbal and cognitive performance.	Molecular autism	Gabrielsen, Terisa P; Anderson, Jeff S; Stephenson, Kevin G; Beck, Jonathan; King, Jace B; Kellems, Ryan; Top Jr, David N; Russell, Nicholas C C; Anderberg, Emily; Lundwall, Rebecca A; Hansen, Blake; South, Mikle	January 2018	Not Determined
30543119	Create Study	Revisiting Abnormalities in Brain Network Architecture Underlying Autism Using Topology-Inspired Statistical Inference.	Brain connectivity	Palande, Sourabh; Jose, Vipin; Zielinski, Brandon; Anderson, Jeffrey; Fletcher, P Thomas; Wang, Bei	February 2019	Not Determined
30113114	Create Study	Sustained versus instantaneous connectivity differentiates cognitive functions of processing speed and episodic memory.	Human brain mapping	King, Jace B; Anderson, Jeffrey S	December 2018	Not Determined
29908310	Create Study	Individual differences in aesthetic engagement are reflected in resting-state fMRI connectivity: Implications for stress resilience.	NeuroImage	Williams, Paula G; Johnson, Kimberley T; Curtis, Brian J; King, Jace B; Anderson, Jeffrey S	October 2018	Not Determined
29728946	Study (563)	Social Responsiveness Scale (SRS) in Relation to Longitudinal Cortical Thickness Changes in Autism Spectrum Disorder.	Journal of autism and developmental disorders	Prigge, Molly B D; Bigler, Erin D; Travers, Brittany G; Froehlich, Alyson; Abildskov, Tracy; Anderson, Jeffrey S; Alexander, Andrew L; Lange, Nicholas; Lainhart, Janet E; Zielinski, Brandon A	October 2018	Relevant
29703592	Create Study	Personalized Intrinsic Network Topography Mapping and Functional Connectivity Deficits in Autism Spectrum Disorder.	Biological psychiatry	Dickie, Erin W; Ameis, Stephanie H; Shahab, Saba; Calarco, Navona; Smith, Dawn E; Miranda, Dayton; Viviano, Joseph D; Voineskos, Aristotle N	August 2018	Not Determined
29251836	Create Study	Longitudinal development of thalamic and internal capsule microstructure in autism spectrum disorder.	Autism research : official journal of the International Society for Autism Research	McLaughlin, Kristine; Travers, Brittany G; Dadalko, Olga I; Dean 3rd, Douglas C; Tromp, Do; Adluru, Nagesh; Destiche, Daniel; Freeman, Abigail; Prigge, Molly D; Froehlich, Alyson; Duffield, Tyler C; Zielinski, Brandon A; Bigler, Erin D; Lange, Nicholas; Anderson, Jeff S; Alexander, Andrew L; Lainhart, Janet E	March 2018	Not Determined

helpcenter.collection.publications-tab

Collection - Publications

The number of Publications is displayed in parentheses next to the tab name. Clicking on any of the Publication Titles will open the Publication in a new internet browsing tab.

Collection Owners, Program Officers, and users with Submission or Administrative Privileges for the Collection may mark a publication as either Relevant or Not Relevant in the Status column.

Frequently Asked Questions

How can I determine if a publication is relevant?

Publications are considered relevant to a collection when the data shared is directly related to the project or collection.
Where does the NDA get the publications?

PubMed, an online library containing journals, articles, and medical research. Sponsored by NiH and National Library of Medicine (NLM).

Glossary

Create Study

A link to the Create an NDA Study page that can be clicked to start creating an NDA Study with information such as the title, journal and authors automatically populated.
Not Determined Publication

Indicates that the publication has not yet been reviewed and/or marked as Relevant or Not Relevant so it has not been determined whether an NDA Study is expected.
Not Relevant Publication

A publication that is not based on data related to the aims of the grant/project associated with the Collection or not based on any data such as a review article and, therefore, an NDA Study is not expected to be created.
PubMed

PubMed provides citation information for biomedical and life sciences publications and is managed by the U.S. National Institutes of Health's National Library of Medicine.
PubMed ID

The PUBMed ID is the unique ID number for the publication as recorded in the PubMed database.
Relevant Publication

A publication that is based on data related to the aims of the grant/project associated with the Collection and, therefore, an NDA Study is expected to be created.

Contact NDA Help Desk

Data Expected List: Mandatory Data Structures

These data structures are mandatory for your NDA Collection. Please update the Targeted Enrollment number to accurately represent the number of subjects you expect to submit for the entire study.

For NIMH HIV-related research that involves human research participants: Select the dictionary or dictionaries most appropriate for your research. If your research does not require all three data dictionaries, just ignore the ones you do not need. There is no need to delete extra data dictionaries from your NDA Collection. You can adjust the Targeted Enrollment column in the Data Expected tab to “0” for those unnecessary data dictionaries. At least one of the three data dictionaries must have a non-zero value.

Data Expected	Targeted Enrollment	Initial Submission	Subjects Submitted	Initial Share	Subjects Shared	Status
Research Subject and Pedigree	170	01/15/2009	170	05/15/2009	170	Approved

To create your project's Data Expected list, use the "+New Data Expected" to add or request existing structures and to request new Data Structures that are not in the NDA Data Dictionary.

If the Structure you need already exists, locate it and specify your dates and enrollment when adding it to your Data Expected list. If you require changes to the Structure you need, select the indicator stating "No, it requires changes to meet research needs," and upload a file containing your requested changes.

If the structure you need is not yet defined in the Data Dictionary, you can select "Upload Definition" and attach the necessary materials to request its creation.

When selecting the expected dates for your data, make sure to follow the standard Data Sharing Regimen and choose dates within the date ranges that correspond to your project start and end dates.

Please visit the Completing Your Data Expected Tutorial for more information.

Data Expected List: Data Structures per Research Aims

These data structures are specific to your research aims and should list all data structures in which data will be collected and submitted for this NDA Collection. Please update the Targeted Enrollment number to accurately represent the number of subjects you expect to submit for the entire study.

Data Expected	Targeted Enrollment	Initial Submission	Subjects Submitted	Initial Share	Subjects Shared	Status
Mullen Scales of Early Learning	3	01/15/2009	3	05/15/2009	3	Approved
ABC Community	129	01/15/2009	129	05/15/2009	129	Approved
ADOS	130	01/15/2009	129	05/15/2009	129	Approved
ADI-R	90	01/15/2009	90	05/15/2009	90	Approved
Expressive Vocabulary Test II (EVT II)	144	07/15/2014	144	11/15/2014	144	Approved
Empathy Quotient (EQ)	54	07/15/2014	54	11/15/2014	54	Approved
Social Responsiveness Scale (SRS)	157	01/15/2009	154	05/15/2009	154	Approved
Wechsler Abbreviated Scale of Intelligence (WASI)	126	01/15/2009	126	05/15/2009	126	Approved
Autistic Spectrum Quotient	59	07/15/2014	59	11/15/2014	59	Approved
Comprehensive Test of Phonological Processing (CTOPP)	159	01/15/2009	159	05/15/2009	159	Approved
Childrens Communication Checklist-2 (CCC-2)	10	07/15/2014	10	11/15/2014	10	Approved
Grooved Pegboard Test	133	01/15/2009	133	05/15/2009	133	Approved
Finger Tapping Test	106	01/15/2009	106	05/15/2009	106	Approved
Developmental Behavior Checklist	141	07/15/2014	141	11/15/2014	141	Approved
Screen for Childhood Anxiety Related Emotional Disorders (SCARED)	135	01/15/2009	135	05/15/2009	135	Approved
Pubertal Development Scale (PDS)	148	01/15/2009	148	05/15/2009	148	Approved
Halstead Reitan Grip Strength	156	01/15/2009	156	05/15/2009	156	Approved
Wechsler Intelligence Scale for Children	69	07/15/2014	69	11/15/2014	69	Approved
DAS-II: Differential Ability Scales	83	01/15/2009	83	05/15/2009	83	Approved
Peabody Picture Vocabulary Test, Fourth Edition	145	07/15/2014	146	11/15/2014	146	Approved
Wechsler Adult Intelligence Scale	119	01/15/2009	119	05/15/2009	119	Approved
Communication Checklist - Adult	22	01/15/2009	22	05/15/2009	22	Approved
Physical Exam	164	01/15/2009	164	05/15/2009	164	Approved
Sensory Profile	117	07/15/2014	117	11/15/2014	117	Approved
Child Anxiety and Depression Scale - Parent (RCAD-P)	150	07/15/2014	150	11/15/2014	150	Approved
Test of Memory and Learning (TOMAL)	110	01/15/2009	110	05/15/2009	110	Approved
Clinical Evaluation of Language Fundamentals (CELF)	158	01/15/2009	158	05/15/2009	158	Approved
Wide Range Achievement Test	77	01/15/2009	77	05/15/2009	77	Approved
Hooper Visual Organization Test	137	01/15/2009	137	05/15/2009	137	Approved
Beck Depression Inventory	91	01/15/2009	91	05/15/2009	91	Approved
Trail Making Test (Child and Adult)	146	01/15/2009	146	05/15/2009	146	Approved
Vineland (Parent and Caregiver)	116	01/15/2009	116	05/15/2009	116	Approved
Imaging (Structural, fMRI, DTI, PET, microscopy)	165	01/15/2009	165	05/15/2009	165	Approved
Toronto Alexithymia Scale	78	01/15/2009	78	05/15/2009	78	Approved
Systemising Quotient	43	01/15/2009	43	05/15/2009	43	Approved

Structure not yet defined

No Status history for this Data Expected has been recorded yet

helpcenter.collection.data-expected-tab

Collection - Data Expected

The Data Expected tab displays the list of all data that NDA expects to receive in association with the Collection as defined by the contributing researcher, as well as the dates for the expected initial upload of the data, and when it is first expected to be shared, or with the research community. Above the primary table of Data Expected, any publications determined to be relevant to the data within the Collection are also displayed - members of the contributing research group can use these to define NDA Studies, connecting those papers to underlying data in NDA.

The tab is used both as a reference for those accessing shared data, providing information on what is expected and when it will be shared, and as the primary tracking mechanism for contributing projects. It is used by both contributing primary researchers, secondary researchers, and NIH Program and Grants Management staff.

Researchers who are starting their project need to update their Data Expected list to include all the Data Structures they are collecting under their grant and set their initial submission and sharing schedule according to the NDA Data Sharing Regimen.

To add existing Data Structures from the Data Dictionary, to request new Data Structure that are not in the Dictionary, or to request changes to existing Data Structures, click "+New Data Expected".

For step-by-step instructions on how to add existing Data Structures, request changes to an existing Structure, or request a new Data Structure, please visit the Completing Your Data Expected Tutorial.

If you are a contributing researcher creating this list for the first time, or making changes to the list as your project progress, please note the following:

Although items you add to the list and changes you make are displayed, they are not committed to the system until you Save the entire page using the "Save" button at the bottom of your screen. Please Save after every change to ensure none of your work is lost.
If you attempt to add a new structure, the title you provide must be unique - if another structure exists with the same name your change will fail.
Adding a new structure to this list is the only way to request the creation of a new Data Dictionary definition.

Frequently Asked Questions

What is an NDA Data Structure?

An NDA Data Structure is comprised of multiple Data Elements to make up an electronic definition of an assessment, measure, questionnaire, etc will have a corresponding Data Structure.
What is the NDA Data Dictionary?

The NDA Data Dictionary is comprised of electronic definitions known as Data Structures.

Glossary

Analyzed Data

Data specific to the primary aims of the research being conducted (e.g. outcome measures, other dependent variables, observations, laboratory results, analyzed images, volumetric data, etc.) including processed images.
Data Item

Items listed on the Data Expected list in the Collection which may be an individual and discrete Data Structure, Data Structure Category, or Data Structure Group.
Data Structure

A defined organization and group of Data Elements to represent an electronic definition of a measure, assessment, questionnaire, or collection of data points. Data structures that have been defined in the NDA Data Dictionary are available at https://nda.nih.gov/general-query.html?q=query=data-structure
Data Structure Category

An NDA term describing the affiliation of a Data Structure to a Category, which may be disease/disorder or diagnosis related (Depression, ADHD, Psychosis), specific to data type (MRI, eye tracking, omics), or type of data (physical exam, IQ).
Data Structure Group

A Data Item listed on the Data Expected tab of a Collection that indicates a group of Data Structures (e.g., ADOS or SCID) for which data may be submitted instead of a specific Data Structure identified by version, module, edition, etc. For example, the ADOS Data Structure Category includes every ADOS Data Structure such as ADOS Module 1, ADOS Module 2, ADOS Module 1 - 2nd Edition, etc. The SCID Data Structure Group includes every SCID Data Structure such as SCID Mania, SCID V Mania, SCID PTSD, SCID-V Diagnosis, and more.
Evaluated Data

A new Data Structure category, Evaluated Data is analyzed data resulting from the use of computational pipelines in the Cloud and can be uploaded directly back to a miNDAR database. Evaluated Data is expected to be listed as a Data Item in the Collection's Data Expected Tab.
Imaging Data

Imaging+ is an NDA term which encompasses all imaging related data including, but not limited to, images (DTI, MRI, PET, Structural, Spectroscopy, etc.) as well as neurosignal data (EEG, fMRI, MEG, EGG, eye tracking, etc.) and Evaluated Data.
Initial Share Date

Initial Submission and Initial Share dates should be populated according to the NDA Data Sharing Terms and Conditions. Any modifications to these will go through the approval processes outlined above. Data will be shared with authorized users upon publication (via an NDA Study) or 1-2 years after the grant end date specified on the first Notice of Award, as defined in the applicable Data Sharing Terms and Conditions.
Initial Submission Date

Initial Submission and Initial Share dates should be populated according to these NDA Data Sharing Terms and Conditions. Any modifications to these will go through the approval processes outlined above. Data for all subjects is not expected on the Initial Submission Date and modifications may be made as necessary based on the project's conduct.
Research Subject and Pedigree

An NDA created Data Structure used to convey basic information about the subject such as demographics, pedigree (links family GUIDs), diagnosis/phenotype, and sample location that are critical to allow for easier querying of shared data.
Submission Cycle

The NDA has two Submission Cycles per year - January 15 and July 15.
Submission Exemption

An interface to notify NDA that data may not be submitted during the upcoming/current submission cycle.

Contact NDA Help Desk

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Associated Studies

Studies that have been defined using data from a Collection are important criteria to determine the value of data shared. The number of subjects column displays the counts from this Collection that are included in a Study, out of the total number of subjects in that study. The Data Use column represents whether or not the study is a primary analysis of the data or a secondary analysis. State indicates whether the study is private or shared with the research community.

Study NameFilter by Study Name	DOIFilter by DOI	AbstractFilter by Abstract	Collection/Study SubjectsFilter by Collection/Study Subjects	Data UsageFilter by Data Usage	StateFilter by State
Examining the validity of the use of ratio IQs in psychological assessments	10.15154/1522624	IQ tests are amongst the most used psychological assessments, both in research and clinical settings. For participants who cannot complete IQ tests normed for their age, ratio IQ scores (RIQ) are routinely computed and used as a proxy of IQ, especially in large research databases to avoid missing data points. However, because it has never been scientifically validated, this practice is questionable. In the era of big data, it is important to examine the validity of this widely used practice. In this paper, we use the case of autism to examine the differences between standard full-scale IQ (FSIQ) and RIQ. Data was extracted from four databases in which ages, FSIQ scores and subtests raw scores were available for autistic participants between 2 and 17 years old. The IQ tests included were the MSEL (N=12033), DAS-II early years (N=1270), DAS-II school age (N=2848), WISC-IV (N=471) and WISC-V (N=129). RIQs were computed for each participant as well as the discrepancy (DSC) between RIQ and FSIQ. We performed two linear regressions to respectively assess the effect of FSIQ and of age on the DSC for each IQ test, followed by additional analyses comparing age subgroups as well as FSIQ subgroups on DSC. Participants at the extremes of the FSIQ distribution tended to have a greater DSC than participants with average FSIQ. Furthermore, age significantly predicted the DSC, with RIQ superior to FSIQ for younger participants while the opposite was found for older participants. These results question the validity of this widely used alternative scoring method, especially for individuals at the extremes of the normal distribution, with whom RIQs are most often employed.	86/17423	Secondary Analysis	Shared
The importance of low IQ to early diagnosis of autism	10.15154/1528140	Some individuals can flexibly adapt to life’s changing demands while others, in particular those with Autism Spectrum Disorder (ASD), find it challenging. The origin of early individual differences in cognitive abilities, the putative tools with which to navigate novel information in life, including in infants later diagnosed with ASD remains unexplored. Moreover, the role of intelligence quotient (IQ) vis-à-vis core features of autism remains debated. We systematically investigate the contribution of early IQ in future autism outcomes in an extremely large, population-based study of 8,000 newborns, infants, and toddlers from the US between 2 and 68 months with over 15,000 cross-sectional and longitudinal assessments, and for whom autism outcomes are ascertained or ruled out by about 2-4 years. This population is representative of subjects involved in the National Institutes of Health (NIH)-funded research, mainly on atypical development, in the US. Analyses using predetermined age bins showed that IQ scores are consistently lower in ASD relative to TD at all ages (p<0.001), and IQ significantly correlates with calibrated severity scores (total CSS, as well as non-verbal and verbal CSS) on the ADOS. Note, VIQ is no better than the full-scale IQ to predict ASD cases. These findings raise new, compelling questions about potential atypical brain circuitry affecting performance in both verbal and nonverbal abilities and that precede an ASD diagnosis. This study is the first to establish prospectively that low early IQ is a major feature of ASD in early childhood.	3/6323	Secondary Analysis	Shared
Prognostic early snapshot stratification of autism based on adaptive functioning	10.15154/0z1c-1d37	A major goal of precision medicine is to predict prognosis based on individualized information at the earliest possible points in development. Using early snapshots of adaptive functioning and unsupervised data- driven discovery methods, we uncover highly stable early autism subtypes that yield information relevant to later prognosis. Data from the National Institute of Mental Health Data Archive (NDA) (n = 1,098) was used to uncover three early subtypes (<72 months) that generalize with 96% accuracy. Outcome data from NDA (n = 2,561; mean age, 13 years) also reproducibly clusters into three subtypes with 99% generalization accuracy. Early snapshot subtypes predict developmental trajectories in non-verbal cognitive, language and motor domains and are predictive of membership in different adaptive functioning outcome subtypes. Robust and prognosis- relevant subtyping of autism based on early snapshots of adaptive functioning may aid future research work via prediction of these subtypes with our reproducible stratification model.	64/3517	Secondary Analysis	Shared
The striatal matrix compartment is expanded in autism spectrum disorder.	10.15154/khn8-jf08	Background: Autism spectrum disorder (ASD) is the second-most common neurodevelopmental disorder in childhood. This complex developmental disorder that manifests with restricted interests, repetitive behaviors, and difficulties in communication and social awareness. The inherited and acquired causes of ASD impact many and diverse brain regions, challenging efforts to identify a shared neuroanatomical substrate for this range of symptoms. The striatum and its connections are among the most implicated sites of abnormal structure and/or function in ASD. Striatal projection neurons develop in segregated tissue compartments, the matrix and striosome, that are histochemically, pharmacologically, and functionally distinct. Immunohistochemical assessment of ASD and animal models of autism described abnormal matrix:striosome volume ratios, with an possible shift from striosome to matrix volume. Shifting the matrix:striosome ratio could result from expansion in matrix, reduction in striosome, spatial redistribution of the compartments, or a combination of these changes. Each type of ratio-shifting abnormality may predispose to ASD but yield different combinations of ASD features. Methods: We developed a cohort of 426 children and adults (213 matched ASD-control pairs) and performed connectivity-based parcellation (diffusion tractography) of the striatum. This identified voxels with matrix-like and striosome-like patterns of structural connectivity. Results: Matrix-like volume was increased in ASD, with no evident change in the volume or organization of the striosome-like compartment. The inter-compartment volume difference (matrix minus striosome) within each individual was 31% larger in ASD. Matrix-like volume was increased in both caudate and putamen, and in somatotopic zones throughout the rostral-caudal extent of the striatum. Subjects with moderate elevations in ADOS (Autism Diagnostic Observation Schedule) scores had increased matrix-like volume, but those with highly elevated ADOS scores had 3.7-fold larger increases in matrix-like volume. Conclusions: Matrix and striosome are embedded in distinct structural and functional networks, suggesting that compartment-selective injury or maldevelopment may mediate specific and distinct clinical features. Previously, assessing the striatal compartments in humans required post mortem tissue. Striatal parcellation provides a means to assess neuropsychiatric diseases for compartment-specific abnormalities in vivo. While this ASD cohort had increased matrix-like volume, other mechanisms that shift the matrix:striosome ratio may also increase the chance of developing the diverse social, sensory, and motor phenotypes of ASD.	174/2166	Secondary Analysis	Shared
Unravelling the Collective Diagnostic Power Behind the Features in the Autism Diagnostic Observation Schedule	10.15154/1421921	Background: Autism is a group of heterogeneous disorders defined by deficits in social interaction and communication. Typically, diagnosis depends on the results of a behavioural examination called the Autism Diagnostic Observation Schedule (ADOS). Unfortunately, administration of the ADOS exam is time-consuming and requires a significant amount of expert intervention, leading to delays in diagnosis and access to early intervention programs. The diagnostic power of each feature in the ADOS exam is currently unknown. Our hypothesis is that certain features could be removed from the exam without a significant reduction in diagnostic accuracy, sensitivity or specificity. Objective: Determine the smallest subset of predictive features in ADOS module-1 (an exam variant for patients with minimal verbal skills). Methodology: ADOS module-1 datasets were acquired from the Autism Genetic Resource Exchange and the National Database for Autism Research. The datasets contained 2572 samples with the following labels: autism (1763), autism spectrum (513), and non-autism (296). The datasets were used as input to 4 different cost-sensitive classifiers in Weka (functional trees, LADTree, logistic model trees, and PART). For each classifier, a 10-fold cross validation was preformed and the number of predictive features, accuracy, sensitivity, and specificity was recorded. Results & Conclusion: Each classifier resulted in a reduction of the number of ADOS features required for autism diagnosis. The LADtree classifier was able to obtain the largest reduction, utilizing only 10 of 29 ADOS module-1 features (96.8% accuracy, 96.9% sensitivity, and 95.9% specificity). Overall, these results are a step towards a more efficient behavioural exam for autism diagnosis.	9/1832	Secondary Analysis	Shared
Automated Autism Diagnosis using Phenotypic and Genotypic Attributes: Phase I	10.15154/1343559	The ultimate goal of this project is to develop a predictive system that can automate the diagnosis process for autism using phenotypic and genotypic attributes for classification. At this time, only a first phase is being pursued: starting with scores from Autism Diagnostic Observation Schedule (ADOS) reports, use data-mining techniques to select the smallest set of the most informative evaluation points that can lead to similar behavioral diagnoses as using all report features. The effort began in March, 2016 after data access to NDAR was granted. This report describes the results from that date through the end of December 2016.	9/1045	Secondary Analysis	Shared
Mapping Along-Tract Commissural and Association White Matter Microstructural Differences in Autistic Children and Young Adults	10.15154/91w9-gc71	Previous diffusion magnetic resonance imaging (dMRI) research has indicated altered white matter microstructure in autism, but the implicated regions are inconsistent across studies. Such prior work has largely used conventional dMRI analysis methods, including the traditional microstructure model, diffusion tensor imaging (DTI). However, these methods are limited in their ability to precisely map microstructural differences and accurately resolve complex fiber configurations. In our study, we investigated white matter microstructure alterations in autism using the refined along-tract analytic approach, BUndle ANalytics (BUAN), with both an advanced microstructure model, the tensor distribution function (TDF) and DTI. We analyzed dMRI data from 365 autistic and neurotypical participants (5-24 years; 34% female) from 10 cohorts to examine commissural and association tracts. Autism was associated with lower fractional anisotropy and higher diffusivity in localized portions of nearly every commissural and association tract examined; these tracts inter-connected a wide range of brain regions, including frontal, temporal, parietal, and occipital regions. Taken together, BUAN and TDF allow robust and spatially precise mapping of microstructural properties in autism. Our findings rigorously demonstrate that white matter microstructure alterations in autism may be greater within specific regions of individual tracts, and that the implicated tracts are distributed across the brain.	25/259	Secondary Analysis	Shared
Social Responsiveness Scale (SRS) in Relation to Longitudinal Cortical Thickness Changes in Autism Spectrum Disorder.	10.5072/1358260	The relationship between brain development and clinical heterogeneity in autism (ASD) is unknown. This study examines the Social Responsiveness Scale (SRS) in relation to the longitudinal development of cortical thickness. Participants (N = 91 ASD, N = 56 TDC; 3-39 years at first scan) were scanned up to three times over a 7-year period. Mixed-effects models examined cortical thickness in relation to SRS score. ASD participants with higher SRS scores showed regionally increased age-related cortical thinning. Regional thickness differences and reduced age-related cortical thinning were found in predominantly right lateralized regions in ASD with decreasing SRS scores over time. Our findings emphasize the importance of examining clinical phenotypes in brain-based studies of ASD.	133/133	Primary Analysis	Shared
Evaluation of Differences in Temporal Synchrony Between Brain Regions in Individuals With Autism and Typical Development	10.15154/1475202	Importance: Despite reports of widespread but heterogenous atypicality of functional connectivity in individuals with autism, little is known regarding the temporal dynamics of functional brain connections and how this relates to autistic traits. Objective: To investigate differences in temporal synchrony between brain regions in individuals with autism and typical development. Design: Cohort and replication sample study. The cohort includes data acquired between December 2016 and April 2018. Aggregate data included in the replication sample were released to the public in August 2012 (ABIDE I) and June 2016 (ABIDE II). Data were analyzed in April 2018. Setting: Population-based study conducted at the University of Utah. Participants: This cohort study, conducted at the University of Utah, included 90 adolescent and adult male participants. A larger sample from the multisite Autism Brain Imaging Data Exchange (ABIDE) was also used as a replication sample. Main Outcomes and Measures: Long duration (30 minutes per subject) of multiband, multi-echo functional magnetic resonance imaging was acquired in order to estimate functional connectivity between brain regions. Sustained connectivity, a measure of functional connectivity duration, as well as lagged temporal dynamics related to functional connectivity, were compared between groups for 361 gray matter regions of interest and a 17-network parcellation. Lagged findings were replicated in the larger ABIDE sample (n=1402). Sustained connectivity findings were also associated with behavioral and cognitive variables. Results: In 52 individuals with autism (mean [SD] age, 27.73 [8.66] years) and 38 controls (mean [SD] age, 27.09 [7.49] years), increases in both sustained connectivity and functional connectivity at several lags were found in individuals with autism compared to controls. Group differences in functional connectivity were replicated in the larger ABIDE dataset at a six second lag. Measures of symptom severity in individuals with autism were positively associated with sustained connectivity values. In controls, sustained connectivity was negatively associated with cognitive processing. Conclusions and Relevance: Whereas the magnitude of functional connectivity in autism is variable across brain regions, participant samples, and development, prolonged temporal synchrony of functional connections is reproducibly observed in autism, suggesting a potential mechanism for core symptoms.	71/90	Primary Analysis	Shared

* Data not on individual level

helpcenter.collection.associated-studies-tab

Collection - Associated Studies

Clicking on the Study Title will open the study details in a new internet browser tab. The Abstract is available for viewing, providing the background explanation of the study, as provided by the Collection Owner.

Primary v. Secondary Analysis: The Data Usage column will have one of these two choices. An associated study that is listed as being used for Primary Analysis indicates at least some and potentially all of the data used was originally collected by the creator of the NDA Study. Secondary Analysis indicates the Study owner was not involved in the collection of data, and may be used as supporting data.

Private v. Shared State: Studies that remain private indicate the associated study is only available to users who are able to access the collection. A shared study is accessible to the general public.

Frequently Asked Questions

How do I associate a study to my collection?

Studies are associated to the Collection automatically when the data is defined in the Study.

Glossary

Associated Studies Tab

A tab in a Collection that lists the NDA Studies that have been created using data from that Collection including both Primary and Secondary Analysis NDA Studies.

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